楮桃叶药浴联合卡泊三醇倍他米松软膏治疗寻常型银屑病的临床效果

Clinical effect of Broussonetia Papyrifolia herb bath combined with Capotriol Betamethasone Ointment in the treatment of psoriasis vulgaris

目的探讨楮桃叶药浴联合卡泊三醇倍他米松软膏治疗寻常型银屑病的临床效果。方法选取2020年3月~2021年2月空军特色医学中心收治的69例寻常型银屑病患者为研究对象,采用抓阄法随机分为治疗组(32例)和对照组(37例)。观察期为4周,治疗组前2周联合楮桃叶药浴及卡泊三醇倍他米松软膏外用,此后2周仅外用卡泊三醇倍他米松软膏;对照组4周内仅外用卡泊三醇倍他米松软膏。比较两组患者治疗2、4周后的瘙痒评分、银屑病面积和严重度指数(PASI)评分及治疗总有效率,并评估治疗安全性。结果治疗2周后,治疗组的瘙痒评分及PASI评分低于对照组,总有效率高于对照组,差异有统计学意义(P<0.05);治疗4周后,治疗组的瘙痒评分低于对照组,差异有统计学意义(P<0.05);治疗4周后,两组PASI评分及总有效率比较,差异无统计学意义(P>0.05)。两组患者均未见严重不良反应。结论楮桃叶药浴联合卡泊三醇倍他米松软膏治疗寻常型银屑病效果显著,安全可靠。

Objective To investigate the clinical effect of Broussonetia Papyrifolia herb bath combined with Capotriol Betamethasone Ointment in the treatment of psoriasis vulgaris.Methods A total of 69 patients with psoriasis vulgaris admitted to Air Force Medical Center of PLA from March 2020 to February 2021 were selected as the research objects.And the patients were randomly divided into the treatment group(32 cases)and the control group(37 cases)according to drawing lots method.The observation period was 4 weeks.The treatment group received Broussonetia Papyrifolia herb bath combined with Capotriol Betamethasone Ointment in the first two weeks,and only topical Capotriol Betamethasone Ointment in the following two weeks.The control group was only given topical Capotriol Betamethasone Ointment for four weeks.The pruritus score,psoriasis area and severity index(PASI)score and total effective rate were compared after 2 and 4 weeks of treatment between the two groups.Results Two weeks after the treatment,the pruritus score and PASI score of the treatment group were lower than those of the control group,and total effective rate of the treatment group was higher than that of the control group,the differences were statistically significant(P<0.05).Four weeks after the treatment,the pruritus score of the treatment group was lower than that of the control group,the difference was statistically significant(P<0.05).Four weeks after the treatment,there were no statistically significant differences in PASI score and total effective rate between the two groups(P>0.05).There were no serious adverse reactions in two groups.Conclusion Broussonetia Papyrifolia herb bath combined with Capotriol Betamethasone Ointment in treating psoriasis vulgaris has remarkable clinical effect,and it is safe and reliable.