多巴丝肼片联合普拉克索治疗帕金森病的效果

Effect of Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole in the treatment of Parkinson′s disease

目的观察分析多巴丝肼片联合普拉克索治疗帕金森病的效果。方法选取2018年10月~2020年6月广东省茂名市电白区人民医院内科收治的94例帕金森病患者作为研究对象,采用奇偶数分配法将其分为对照组(47例)和观察组(47例)。对照组患者采用多巴丝肼片药物治疗,观察组患者采用多巴丝肼片联合普拉克索治疗。比较两组患者用药前后的韦氏综合评定量表(Webster)评分、帕金森病评定量表第Ⅲ部分运动检查评价(UPDRSⅢ)评分,比较两组患者的治疗总有效率。结果两组患者用药前的Webster、UPDRSⅢ评分比较,差异无统计学意义(P>0.05);用药2个月后,两组患者的Webster、UPDRSⅢ评分均低于用药前,差异有统计学意义(P<0.05);且观察组患者用药2个月后的Webster、UPDRSⅢ评分均低于对照组,差异有统计学意义(P<0.05);观察组患者的治疗总有效率(89.36%)高于对照组(61.70%),差异有统计学意义(P<0.05)。结论多巴丝肼片联合普拉克索治疗帕金森病患者的有效性较多巴丝肼片单一用药有明显提升,能有效改善患者的临床症状,控制其病情发展,药用价值较高,值得临床应用。

Objective To observe the effect of Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole in the treatment of Parkinson′s disease.Methods Ninety-four patients with Parkinson′s disease admitted to the Internal Medicine Department of Dianbai District People′s Hospital of Maoming City,Guangdong Province from October 2018 to June 2020 were selected as the research subjects.They were divided into a control group(n=47)and an observation group(n=47)using the odd/even number distribution method.Patients in the control group were treated with Levodopa and Benserazide Hydrochloride Tablets.Patients in the observation group were provided with Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole.The Webster comprehensive rating scale(Webster)score and the Parkinson′s disease rating scaleⅢpart motor examination evaluation(UPDRSⅢ)score before and after medication were compared between the two groups,and the total effective rate of the two groups was compared.Results Webster and UPDRSⅢscores before medication in the two groups were compared,and the differences were not statistically significant(P>0.05).After two months of medication,the Webster and UPDRSⅢscores of the two groups were lower than those before medication,and the differences were statistically significant(P<0.05).The Webster and UPDRSⅢscores of the observation group after two months of medication were lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of observation group(89.36%)was higher than that of control group(61.70%),and the difference was statistically significant(P<0.05).Conclusion The effectiveness of the treatment of patients with Parkinson′s disease is significantly improved in the combination of Levodopa and Benserazide Hydrochloride Tablets and Pramipexole compared with Levodopa and Benserazide Hydrochloride Tablets alone.It can effectively improve the clinical symptoms of patients and control the development of their disease.It has high medicinal value and is worthy of clinical application.