基因组不稳定性与淋巴瘤

Genome instability and lymphoma

淋巴瘤是最常见血液系统恶性肿瘤之一,基因组不稳定性是淋巴瘤发生和发展的重要分子基础,对淋巴瘤的诊断和预后有重要价值。基因组不稳定性包括基因水平的微卫星不稳定性(microsatellite instability,MSI/MIN)和染色体水平的染色体不稳定性(chromosomal instability,CIN)2种类型。通过对淋巴瘤相关基因改变的研究,寻找与淋巴瘤发生相关的不稳定基因,探索其参与淋巴瘤发生和发展的机制,能为淋巴瘤精准医学研究提供重要的分子生物学依据。

Lymphoma is one of the most common malignant tumor of the hematologic system.The genome instability is not only an important molecular basis for the development of lymphoma,but also has important value in the diagnosis and prognosis of lymphoma.There are 2 types of genome instability:Microsatellite instability(MSI/MIN)at gene level and chromosomal instability at chromosome level.Through the study on genes associated with lymphoma,the unstable genes associated with lymphoma could be found,meanwhile the mechanism of its occurrence and development of lymphoma could be explored,and the important basis of molecular biology could also be provided in the field of current hot lymphoma precision medical research.