辛复宁治疗慢性宫颈炎伴HR-HPV感染的疗效观察

Observation on the curative effect of Xinfuning in the treatment of chronic cervicitis with HR-HPV infection

目的:研究辛复宁治疗慢性宫颈炎伴高危型人乳头瘤病毒(HR-HPV)感染的临床疗效。方法:2019年3月-2020年6月收治慢性宫颈炎伴HR-HPV感染患者120例,按照治疗方法不同分为两组,各60例。对照组采用常规治疗方案;观察组在常规治疗基础上加用辛复宁治疗。比较两组患者HPV转阴情况、临床指标及血清炎性因子水平。结果:观察组HPV转阴率高于对照组,差异有统计学意义(P<0.05);观察组愈合时间、分泌物量及接触性出血率均低于对照组,差异有统计学意义(P<0.05);观察组治疗后肿瘤坏死因子-α、C-反应蛋白及白细胞介素-6水平均低于对照组,差异有统计学意义(P<0.05)。结论:辛复宁治疗慢性宫颈炎伴HR-HPV感染患者的疗效确切,可有效提高HPV清除效果,抑制机体炎症反应,进而缓解临床症状,改善预后。

Objective:To study the clinical efficacy of Xinfuning in the treatment of chronic cervicitis with high-risk human papillomavirus(HR-HPV)infection.Methods:From March 2019 to June 2020,120 cases of patients with chronic cervicitis with HR-HPV infection were enrolled,they were divided into two groups according to the treatment plans,with 60 cases in each groups.The control group was treated with routine treatment.The observation group was treated with Xinfuning on the basis of routine treatment.The HPV turned to negative status,clinical index levels and serum inflammatory factor levels were compared between the two groups of patients.Results:The HPV turned to negative rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The healing time,secretion volume and contact bleeding rate in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The levels of tumor necrosis factor-α,C-reactive protein and interleukin-6 in the observation group were lower than those in the control group after treatment,the differences were statistically significant(P<0.05).Conclusion:Xinfuning is effective in treating chronic cervicitis with HR-HPV infection,which can effectively improve the effect of HPV clearance,inhibit the body's inflammatory response and then alleviate clinical symptoms,the prognosis of patients is also improved.