手术致脑损伤的基础研究进展

Progress in basic research of surgically-induced brain injury

手术致脑损伤(SBI)是指在神经外科手术实施的过程中,由于手术器械对脑组织的切割、牵拉和术中出血等多方面因素,手术病灶周边健康的脑组织受到的不可避免的脑损伤。这种特殊的脑损伤将引起脑水肿、脑出血和神经元死亡等继发性病变,是影响手术预后的重要因素之一。近年来,关于SBI的基础研究已经取得部分进展。本文就现有SBI动物模型的构建方法、相关分子机制和治疗方法展开综述,以期为探索SBI的发病机制提供依据,为临床治疗方法的应用和开发提供参考。

Surgically-induced brain injury(SBI)refers to the healthy brain surrounding the surgical lesion suffers inevitable brain injury due to various factors such as the cutting and retraction of the brain tissue by surgical instruments,and intraoperative bleeding during the implementation of neurosurgery.This special brain injury is one of the important factors affecting the prognosis of surgery which will cause secondary lesions such as brain edema,cerebral hemorrhage and neuronal death.In recent years,basic research on SBI has made some progress.In this paper,the construction methods of SBI animal models,related molecular mechanisms and treatment methods are review,in order to provide the basis for exploring the pathogenesis of SBI and provide reference for the application and development of clinical treatment methods.