尿毒清颗粒联合氢氯噻嗪治疗慢性肾功能衰竭的临床研究

Clinical study of Niaoduqing Granules combined with Hydrochlorothiazide in the treatment of chronic renal failure

目的探讨慢性肾功能衰竭(CRF)患者经氢氯噻嗪联合尿毒清颗粒治疗后的临床效果。方法采用随机数字表法将2018年1月—2020年1月安徽省阜阳市第二人民医院收治的CRF患者(126例)分为对照组(63例)和观察组(63例)。对照组给予氢氯噻嗪治疗,观察组给予尿毒清颗粒联合氢氯噻嗪治疗,疗程为8周。记录两组治疗后的效果、症状改善时间。比较两组治疗前、后的炎症因子、肾功能指标,治疗期间不良反应情况。结果观察组总有效率高于对照组(P<0.05)。观察组乏力、浮肿、食欲缺乏、恶心症状改善时间短于对照组(P<0.05)。治疗8周后,两组白细胞介素-1β、肌酐、肿瘤坏死因子-α、尿素氮、白细胞介素-6水平较治疗前降低,且观察组低于对照组(P<0.05)。与治疗前比较,治疗8周后,两组内生肌酐清除率升高,且观察组高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论尿毒清颗粒联合氢氯噻嗪治疗CRF患者,可有效促进症状改善,降低微炎症状态,延缓肾衰进程,安全可靠,疗效值得认可。

Objective To investigate the clinical effect of Niaoduqing Granules combined with Hydrochlorothiazide in the treatment of chronic renal failure(CRF).Methods A total of 126 patients with CRF in Fuyang Second People’s Hospital from January 2018 to January 2020 were selected,they were divided into control group(63 cases)and observation group(63 cases).The control group was treated with Hydrochlorothiazide,and the observation group was treated with Nuiduqing Granules combined with Hydrochlorothiazide,the course of treatment was 8 weeks.The effect and symptom improvement time after treatment were recorded.Inflammatory factors,renal function indexes and adverse reactions during treatment were compared between the two groups before and after treatment.Results The total effective rate of observation group was higher than that of control group(P<0.05).The improvement time of fatigue,edema,anorexia and nausea in the observation group were shorter than those in the control group(P<0.05).After 8 weeks of treatment,the levels of interleukin-1β,creatinine,tumor necrosis factor-α,urea nitrogen and interleukin-6 in both groups were decreased than before treatment,and the observation group was lower than the control group(P<0.05).Compared with before treatment,after 8 weeks of treatment,the clearance rate of endogenous creatinine in both groups was increased,and the observation group was higher than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Niaoduqing Granules combined with Hydrochlorothiazide in the treatment of CRF patients can effectively promote the improvement of symptoms,reduce the micro inflammatory state,delay the process of renal failure,which is safe and reliable,and the curative effect is worthy of recognition.