电项针联合药物治疗脑小血管病认知功能障碍的效果

Effect of electric nape acupuncture combined with drugs on cognitive dysfunction of cerebral small vessel disease

目的探讨电项针联合药物治疗脑小血管病(CSVD)患者认知功能障碍的效果。方法选取2018年4月—2020年10月黑龙江中医药大学附属第二医院门诊及病房收治的72例CSVD患者,采用随机数字表法将其分为对照组与治疗组,每组36例。对照组给予口服药物、针灸、对症基础治疗;治疗组在对照组基础上联合电项针疗法,两组均治疗8周。两组分别在治疗前、治疗后2周、治疗后8周应用蒙特利尔认知功能量表(MoCA)及简易精神量表(MMSE)进行评定。结果72例患者中实际完成观察69例,脱落3例。其中,对照组完成观察35例,治疗组完成观察34例。组间比较、时间点比较及交互作用差异均有统计学意义(P<0.05)。组内比较:两组治疗8周后的MoCA、MMSE评分均明显高于两组治疗前和治疗2周后,差异均有统计学意义(均P<0.05),两组治疗前和治疗2周后MoCA、MMSE评分比较,差异无统计学意义(P>0.05);组间比较:治疗前与治疗2周后,两组MoCA、MMSE评分比较,差异无统计学意义(P>0.05),治疗8周后,治疗组MoCA、MMSE评分明显高于对照组,差异均有统计学意义(均P<0.05)。结论电项针疗法可以提高CSVD认知功能障碍患者MMSE、MoCA量表评分,改善认知功能,且疗程越长,获益越佳。

Objective To investigate the effect of electric nape acupuncture combined with drugs on the cognitive dys function of patients with cerebral small vessel disease(CSVD).Methods A total of 72 patients with CSVD admitted to the outpatient department and ward of Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from April 2018 to October 2020 were selected and they were divided into control group and treatment group by random number table method,with 36 patients in each group.The control group received oral medicine,acupuncture,symptomatic basic treatment.The treatment group was combined with electric nape acupuncture therapy on the basis of the control group,and both groups were treated for eight weeks.The Montreal cognitive assessment scale(MOCA)and the mini-mental state examination(MMSE)were used to assess the two groups before,two weeks and eight weeks after treatment,respectively.Results Of the 72 patients,69 cases were actually observed and three cases were abscission.Among them,35 cases in the control group and 34 cases in the treatment group completed observation.There were statistically significant differences in comparison between groups,time point comparison and interaction(P<0.05).Comparison within groups:MoCA and MMSE scores of the two groups after eight weeks of treatment were significantly higher than those before and after two weeks of treatment,the differences were statistically significant(all P<0.05).There were no significant differences in MoCA and MMSE scores between the two groups before treatment and two weeks after treatment(P>0.05).Comparison between groups:there were no significant differences in MoCA and MMSE scores between the two groups before treatment and two weeks after treatment(P>0.05).After eight weeks of treatment,MoCA and MMSE scores in the treatment group were significantly higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Electric nape acupuncture therapy can improve the MMSE and MoCA scores of patients with cognitive dysfunction of CSVD,and improve the cognitive function,and the longer the course of treatment,the better the benefit.