人工流产术后口服优思明对其恢复情况及宫腔粘连发生率的研究

Study on recovery and incidence of intrauterine adhesions after induced abortion by oral usmine

目的探讨人工流产术后患者口服屈螺酮炔雌醇片(优思明)对其恢复效果及宫腔粘连发生情况。方法选取110例行人工流产手术患者,按照就诊顺序将患者分为对照组与试验组,每组55例。对照组予以戊酸雌二醇片(补佳乐)治疗,试验组予以优思明治疗,对比两组患者治疗优良率、治疗前后血清炎性因子、各项指标恢复情况及术后宫腔粘连发生情况。结果对照组患者优良率为76.36%,试验组患者优良率为96.36%,试验组患者优良率明显高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者C反应蛋白(CRP)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者CRP、IL-6、IL-8水平均明显低于治疗前,且试验组明显低于对照组,差异具有统计学意义(P<0.05)。试验组术后出血量明显少于对照组,月经复潮时间、阴道持续出血时间均明显短于对照组,子宫内膜厚度厚于对照组,差异有统计学意义(P<0.05)。试验组术后未发生一例宫腔粘连,对照组术后发生7例宫腔粘连,发生率为12.73%,两组比较差异有统计学意义(P<0.05)。结论针对行人工流产手术患者,口服优思明可减少出血量,缩短月经复潮时间及阴道持续出血时间,促进子宫内膜修复,降低患者炎性因子水平,减少宫腔粘连发生,促进术后恢复。

Objective To investigate the effect of oral administration of drospiroone ethinylestradiol tablets(Yosmine)on the recovery of patients after induced abortion and the incidence of intrauterine adhesions.Methods A total of 110 patients with induced abortion were selected and divided into control group and experimental group according to the order of treatment,with 55 cases in each group.The control group was treated with estradiol valerate tablet(bujiale),and the experimental group was treated with Yosmine.The excellent and good rates of treatment,the recovery of serum infl ammatory factors,various indicators before and after treatment,and the incidence of postoperative intrauterine adhesions were compared between the two groups.Results The excellent and good rate was 76.36%in the control group and 96.36%in the experimental group.The excellent and good rate in the experimental group was signifi cantly higher than that in the control group,the difference being statistically signifi cant(P<0.05).Before treatment,there were no signifi cant differences in the levels of C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-8(IL-8)between 2 groups(P>0.05).After treatment,the levels of CRP,IL-6 and IL-8 in 2 groups were significantly lower than before treatment,and the test group was significantly lower than the control group,the difference was statistically significant(P<0.05).The amount of postoperative bleeding in the experimental group was signifi cantly less than that in the control group,the time of menstrual return to menstruation and continuous vaginal bleeding were signifi cantly shorter than that in the control group,and the thickness of endometrium was thicker than that in the control group,the difference was statistically signifi cant(P<0.05).No postoperative intrauterine adhesions occurred in the experimental group,while 7 cases of intrauterine adhesions occurred in the control group(12.73%).The difference between the two groups was statistically significant(P<0.05).Conclusion For patients undergoing induced abortion,oral usamin can reduce the amount of bleeding,shorten the time of menstrual return to menstruation and continuous vaginal bleeding,promote endometrial repair,reduce the level of inflammatory factors in patients,reduce the incidence of intrauterine adhesions,and promote postoperative recovery.