茵陈蒿汤加减治疗妊娠期肝内胆汁淤积症疗效观察

Observation on the therapeutic effect of Yin Chenhao decoction on intrahepatic cholestasis during pregnancy

目的探究针对妊娠期肝内胆汁淤积症(ICP)患者采用茵陈蒿汤加减治疗的临床疗效。方法选取30例妊娠期肝内胆汁淤积症患者,采用随机数字表法分为对照组与研究组,每组15例。对照组患者给予单纯熊去氧胆酸治疗,研究组患者给予熊去氧胆酸联合茵陈蒿汤加减治疗,比较两组患者治疗前后实验室指标、临床疗效、妊娠结局。结果治疗前,两组患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、胆汁酸指标比较,差异无统计学意义(P>0.05);治疗14 d后,研究组患者ALT、AST以及胆汁酸指标均明显低于对照组,差异具有统计学意义(P<0.05)。研究组患者治疗总有效率为93.33%,明显高于对照组的60.00%,差异有统计学意义(P<0.05)。研究组患者早产、羊水污染、胎儿窘迫以及产后出血例数占比均明显低于对照组,差异有统计学意义(P<0.05)。结论茵陈蒿汤加减应用于妊娠期肝内胆汁淤积症患者临床治疗中具有显著效果,可促使患者肝功能恢复正常,有效降低胆汁酸水平,并改善妊娠结局。

Objective To explore the clinical value of Yinchenhao decoction in the treatment of intrahepatic cholestasis of pregnancy(ICP).Methods 30 patients with intrahepatic cholestasis during pregnancy were divided into control group and study group by random number table method,with 15 cases in each group.Patients in the control group were treated with ursodeoxycholic acid alone,and patients in the research group were treated with ursodeoxycholic acid combined with Yinchenhao decoction.The laboratory indicators,clinical effi cacy and pregnancy outcome of the two groups were compared before and after treatment.Results Before treatment,there were no signifi cant differences in ALT,AST and bile acid indexes between 2 groups(P>0.05).After 14 days of treatment,the indexes of ALT,AST and bile acid in the study group were signifi cantly lower than those in the control group,with statistical signifi cance(P<0.05).The total effective rate in the study group was 93.33%,which was signifi cantly higher than that in the control group(60.00%),and the difference was statistically signifi cant(P<0.05).The proportion of premature delivery,amniotic fl uid pollution,fetal distress and postpartum hemorrhage in the study group was signifi cantly lower than that in the control group,with statistical signifi cance(P<0.05).Conclusion The treatment of patients with intrahepatic cholestasis during pregnancy with modifi ed Yinchenhao decoction has a signifi cant effect,can promote the recovery of liver function,effectively reduce the level of bile acid,and improve the pregnancy outcome of pregnant women.