硫酸氨基葡萄糖治疗膝骨关节炎疗效和安全性

Efficacy and Safety of Glucosamine Sulfate in the Treatment of Knee Osteoarthritis

目的:探讨硫酸氨基葡萄糖对膝骨关节炎的治疗效果及安全性,为膝骨关节炎的治疗提供一定依据。方法:收集2015年7月至2020年6月期间在石河子大学第一附属医院收治的128例膝骨关节炎患者资料,根据治疗方式分为A、B两组,A组口服硫酸氨基葡萄糖胶囊联合外用双氯芬酸二乙胺乳胶剂治疗,B组外用双氯芬酸二乙胺乳胶剂治疗。结果:治疗后,A组总有效率94.03%,B组总有效率73.77%,两组比较差异具有统计学意义(P<0.05);两组患者WOMAC评分、VAS评分均降低,且A组低于B组,差异具有统计学意义(P<0.05);两组患者IL-β1、IL-6、CRP、ESR水平均低于治疗前,且A组低于B组,差异具有统计学意义(P<0.05)。结论:硫酸氨基葡萄糖可以缓解膝骨关节炎患者疼痛症状,临床疗效好,安全性高。

Objective:To investigate the efficacy and safety of glucosamine sulfate in the treatment of knee osteoarthritis,and to provide a certain basis for the treatment of knee osteoarthritis.Methods:Data of 128 patients with knee osteoarthritis admitted to the First Affiliated Hospital of Shihezi University from July 2015 to June 2020 were collected and divided into group A and group B according to treatment methods.Group A was treated with oral glucosamine sulfate capsule combined with topical diclofenac diethyl amine latex,and group B was treated with topical diclofenac diethyl amine latex.Results:After treatment,the total effective rate of group A was 94.03%,and that of group B was 73.77%(P<0.05).WOMAC score and VAS score in 2 groups were decreased,and group A was lower than group B,the difference was statistically significant(P<0.05).IL-1β,IL-6,CRP and ESR levels in 2 groups were lower than before treatment,and group A was lower than group B,the difference was statistically significant(P<0.05).Conclusion:Glucosamine sulfate can relieve the pain symptoms of patients with knee osteoarthritis,with good clinical efficacy and high safety.