布地奈德联合阿奇霉素治疗小儿肺炎支原体感染的临床效果分析

Clinical effect analysis of budesonide combined with azithromycin in the treatment of children with mycoplasma pneumoniae infection

目的:探究阿奇霉素联合布地奈德雾化吸入治疗小儿肺炎支原体感染的临床效果。方法:2018年10月-2020年9月收治MP感染患儿100例,随机分为两组,各50例。对照组应用阿奇霉素注射治疗;观察组在阿奇霉素基础上联合布地奈德雾化吸入治疗。比较两组治疗效果。结果:观察组治疗后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)等炎症因子指标水平均明显低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:应用布地奈德联合阿奇霉素治疗MP感染的效果显著,可有效改善发热、咳嗽等相关症状,降低炎症反应,安全性较高,可应用于临床治疗。

Objective:To explore the clinical effect of azithromycin combined with budesonide atomization inhalation in the treatment of mycoplasma pneumoniae infection in children.Methods:From October 2018 to September 2020,100 cases of children with mycoplasma pneumoniae infection were enrolled,they were randomly divided into two groups with 50 cases in each group.The control group was treated with azithromycin injection.The observation group was treated with budesonide atomization inhalation on the basis of azithromycin.The therapeutic effects between the two groups was compared.Results:The levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C reactive protein(CRP)in the observation group were significantly lower than those in the control group after treatment,the differences were statistically significant(P<0.05).The incidence of adverse reaction between the two groups was compared,the difference was not statistically significant(P>0.05).Conclusion:The effect of budesonide combined with azithromycin on MP infection is remarkable,it can effectively improve fever,cough and other related symptoms,reduce inflammatory response,with high safety,which can be used in clinical treatment.