PC方案同步放化疗治疗局部晚期肺腺癌的近期和远期疗效分析

Short-term and long-term efficacy analysis of concurrent radiotherapy and chemotherapy with PC regimen for locally advanced lung adenocarcinoma

目的探讨PC方案同步放化疗应用于局部晚期肺腺癌患者的临床效果,并评价其对患者生存率的影响。方法选取2014年3月至2017年1月我院收治的局部晚期肺腺癌患者89例作为研究对象,采用随机数字表法将其分为PC组(n=46)和对照组(n=43),其中对照组患者实施DC方案化疗,PC组患者实施PC方案同步放化疗。观察两组患者的近期疗效、不良反应及生存率。结果PC组患者总有效率为89.13%,显著高于对照组的67.44%,差异有统计学意义(χ^(2)=6.226,P<0.05);PC组患者不良反应总发生率为17.39%,显著低于对照组的41.86%,差异有统计学意义(P<0.05)。出院后2年,PC组的生存率为86.96%,显著高于对照组的69.77%,差异有统计学意义(χ^(2)=3.911,P<0.05);出院后3年,PC组生存率为78.26%,显著高于对照组的51.16%,差异有统计学意义(χ^(2)=7.190,P<0.05)。结论PC方案同步放化疗能明显改善局部晚期肺腺癌患者的近期疗效及远期疗效。

Objective To investigate the clinical effect of concurrent radiotherapy and chemotherapy with PC regimen in patients with locally advanced lung adenocarcinoma(ALA),and to evaluate its influence on the survival rate of patients.Methods A total of 89 patients with locally ALA admitted to our hospital from March 2014 to January 2017 were selected as the research objects.They were divided into the PC group(n=46)and the control group(n=43)by random number table method.The control group was received DC regimen with chemotherapy and the PC group was received PC regimen with concurrent radiotherapy and chemotherapy.The short-term curative effect,adverse reactions and survival rate between the two groups were observed and compared.Results The total effective rate was 89.13%in the PC group,which was significantly higher than that of 67.44%in the control group,with significant difference(χ^(2)=6.226,P<0.05).The total adverse reaction rate in the PC group was 17.39%,which was significantly lower than that of 41.86%in the control group,with significant difference(P<0.05).Two years after discharge,the survival rate in the PC group was 86.96%,which was significantly higher than that of 69.77%in control group,with significant difference(χ^(2)=3.911,P<0.05).Three years after discharge,the survival rate was 78.26%in the PC group,which was significantly higher than that of 51.16%in the control group,with significant difference(χ^(2)=7.190,P<0.05).Conclusion PC regimen with concurrent radiotherapy and chemotherapy can significantly improve the short-term and long-term efficacy of patients with locally ALA.