温和灸联合西药治疗放射性肠炎的临床观察

Clinical Observation of Mild Moxibustion Combined with Western Medication for Radiation Enteritis

目的观察温和灸联合西药治疗放射性肠炎的临床疗效。方法将70例放射性肠炎患者随机分为对照组和观察组,每组35例。对照组予西药治疗,观察组予温和灸联合西药治疗。治疗前后分别评估肠道黏膜损伤分级、Karnofsky功能状态(KPS)评分,测定血清胰高血糖素样肽-2(GLP-2)、白介素(IL)-17水平,并比较两组临床疗效。结果治疗后,观察组总有效率高于对照组(P<0.05)。治疗后,对照组肠道黏膜损伤分级较治疗前未见明显改善(P>0.05),而观察组治疗后肠道黏膜损伤分级较治疗前明显改善(P<0.05),且优于对照组治疗后(P<0.05)。治疗后,两组KPS评分均高于治疗前(P<0.05),且观察组治疗后KPS评分高于对照组(P<0.05)。对照组治疗后血清GLP-2、IL-17水平与治疗前比较,差异无统计学意义(P>0.05);观察组治疗后血清GLP-2、IL-17水平较治疗前明显改善(P<0.05),且优于对照组治疗后(P<0.05)。结论温和灸联合西药治疗放射性肠炎疗效优于单纯西药治疗,可促进肠道黏膜修复,改善患者生活质量,可能与其调节血清GLP-2和IL-17水平有关。

Objective To observe the clinical efficacy of mild moxibustion plus Western medication in treating radiation enteritis.Method Seventy patients with radiation enteritis were randomized into a control group and an observation group,with 35 cases in each group.The control group was treated with Western medication while the observation group was given Western medication together with mild moxibustion.The intestinal mucosal injury grading and Karnofsky performance score(KPS)were estimated and the levels of serum glucagon-like peptide-2(GLP-2)and interleukin(IL)-17 were determined before and after treatment in the two groups.Clinical efficacy was also compared.Result After treatment,the total effective rate was higher in the observation group than in the control group(P<0.05).There was no significant improvement in intestinal mucosal injury grading in the control group after intervention(P>0.05),while significant improvement was found in intestinal mucosal injury grading in the observation group(P<0.05),and the observation group was superior to the control group after treatment(P<0.05).KPS score increased in both groups after intervention(P<0.05),and was higher in the observation group than in the control group(P<0.05).The levels of serum GLP-2 and IL-17 showed no significant changes in the control group after intervention(P>0.05);the levels of GLP-2 and IL-17 showed significant improvements in the observation group after treatment(P<0.05),and were better than those in the control group(P<0.05).Conclusion Mild moxibustion plus Western medication can produce more significant efficacy than Western medication alone in treating radiation enteritis;it can boost the repair of intestinal mucosa and improve the quality of life of the patients,which may be associated with its regulation of serum GLP-2 and IL-17 levels.