宁泌泰胶囊联合托特罗定对女性膀胱过度活动症患者尿流动力学及神经生长因子、脑源性神经营养因子表达的影响

Effect of Ningmitai Capsule Combined with Tolterodine on Urodynamics and Expressions of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Female Overactive Bladder

目的:探讨宁泌泰胶囊联合托特罗定对女性膀胱过度活动症(OAB)患者尿流动力学及神经生长因子(NGF)、脑源性神经营养因子(BDNF)表达的影响。方法:选取2019年10月~2020年10月于本院泌尿外科就诊的120例女性OAB患者作为研究对象,采用随机数字表法分为对照组和观察组,各60例。对照组给予托特罗定治疗,观察组在对照组基础上给予宁泌泰胶囊治疗。比较两组总有效率、膀胱过度活动症评分(OABSS)、尿流动力学指标[最大膀胱测压容量(MCC)、最大逼尿肌压(P_(det·max))、最大尿道闭合压(MUCP)、最大尿流率(MFR)]、NGF和BDNF水平及其与尿肌酐(UCr)的比值(NGF/UCr和BDNF/UCr),以及不良反应发生情况。结果:观察组总有效率高于对照组(P<0.05)。治疗后,两组OABSS评分低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组MCC、P_(det·max)、MUCP、MFR均优于治疗前,且观察组优于对照组(P<0.05)。治疗后,两组NGF、BDNF、NGF/UCr、BDNF/UCr均低于治疗前,且观察组低于对照组(P<0.05)。两组口干、头晕、头痛、便秘、排尿困难、视物模糊发生率比较均无统计学差异(P>0.05)。结论:宁泌泰胶囊联合托特罗定治疗女性OAB疗效较佳,安全性较好,可改善患者临床症状和尿流动力学指标,调节NGF、BDNF的表达。

Objective:To explore the effect of Ningmitai capsule combined with tolterodine on urodynamics and expressions of nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)in female overactive bladder(OAB).Methods:A total of 120 female OAB admitted in the urology surgery clinic of our hospital from October 2019 to October 2020 were selected as the research objects,and they were divided into control group and observation group by the random number table method,with 60 cases in each group.The control group was treated with tolterodine,whereas the observation group was treated with Ningmitai capsule on the basis of the control group.The total effective rate,overactive bladder symptom score(OABSS),urodynamic indicators[maximum cystometric capacity(MCC),maximum detrusor pressure(P_(det·max)),maximum urethral closure pressure(MUCP),maximum flow rate(MFR)],levels of NGF and BDNF,their ratios to urine creatinine(UCr)(NGF/UCr and BDNF/UCr)and occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the OABSS scores of the two groups were lower than those before treatment,and the scores in the observation group was lower than that in the control group(P<0.05).After treatment,the MCC,P_(det·max),MUCP and MFR of the two groups were better than those before treatment,and the above indicators in the observation group were better than those in the control group(P<0.05).After treatment,the NGF,BDNF,NGF/UCr and BDNF/UCr of the two groups were lower compared with those before treatment,and the above indicators in the observation group were lower than those in the control group(P<0.05).There were no significant differences in the incidence rates of dry mouth,dizziness,headache,constipation,dysuria and blurred vision between the two groups(P>0.05).Conclusion:Ningmitai capsule combined with tolterodine has better efficacy and safety in the treatment of female OAB.It can improve the clinical symptoms and urodynamic indicators,and regulate the expressions of NGF and BDNF.