以超声检测为基础的NALFD肝脏脂肪变性的无创诊断

Ultrasound-based techniques for noninvasive diagnosis of liver steatosis in nonalcoholic fatty liver disease

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)已成为全球普遍关注的医学问题和社会问题,尽管非酒精性肝脏脂肪变性可以逆转,但是仍然有部分患者进展成为NASH、肝硬化甚至肝癌,因此NAFLD的早期诊断、准确疾病评估成为NAFLD干预治疗、改善预后的重要基础.尽管肝活检作为NAFLD诊断的金标准,但并不是一个理想的参考标准,而MRI-PDFF更多用于临床研究中.以超声检测为基础的非侵入性检查也成为NAFLD研究的热点,本文对NAFLD的肝脏脂肪变性的超声诊断技术进行分析,为NAFLD的诊断、疾病评估、治疗干预提供安全和实用的依据.

Nonalcoholic fatty liver disease(NAFLD)has become a worldwide medical and social problem.Although nonalcoholic steatosis can be reversed,some patients still progress to nonalcoholic steatohepatitis,liver cirrhosis,and even liver cancer.Therefore,early diagnosis and accurate disease assessment of NAFLD have become an important basis for its intervention treatment and prognosis improvement.Although liver biopsy is the gold standard for the diagnosis of NAFLD,it is not an ideal reference standard,and MRI-PDFF is more often used in clinical research.The non-invasive examination based on ultrasound detection has also become a hot spot of NAFLD research.This paper discusses the ultrasonic diagnosis technology for liver steatosis in NAFLD,with an aim to provide a safe and practical basis for the diagnosis,disease evaluation,and treatment intervention of NAFLD.