二丹红藤败酱汤联合抗菌药物治疗盆腔炎性疾病疗效评价

Efficacy Evaluation on Erdan Hongteng Baijiang Decoction Combined with Antibiotics for Treatment of Pelvic Inflammatory Disease

目的评价二丹红藤败酱汤联合抗菌药物治疗盆腔炎性疾病的临床疗效。方法回顾性分析2016年12月-2020年7月六安市中医院盆腔炎性疾病患者,采用SPSS22.0进行倾向性评分匹配分为观察组和对照组各53例。观察组采用二丹红藤败酱汤联合抗菌药物治疗,对照组单用抗菌药物治疗。2组疗程均为4周。比较2组临床疗效、抗菌药物使用时间、血清炎症和免疫学指标水平,并评价2组用药安全性。结果观察组总有效率为92.5%(49/53),对照组为77.4%(41/53),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后中医症状各项评分明显下降(P<0.05);2组治疗后比较,观察组中医症状各项评分明显低于对照组(P<0.01)。观察组抗菌药物使用平均时间少于对照组(P<0.05)。与本组治疗前比较,2组治疗后血IgG水平较治疗前明显下降,C3、C4水平明显上升(P<0.05);2组治疗后比较,观察组血Ig G水平明显低于对照组,C3、C4水平明显高于对照组(P<0.01)。观察组、对照组分别发生不良反应7、6例,2组不良反应发生率比较差异无统计学意义(P>0.05)。结论二丹红藤败酱汤联合抗菌药物可显著提高盆腔炎性疾病的临床疗效,调节并改善患者炎症因子水平和机体免疫功能。

Objective To explore the clinical efficacy of Erdan Hongteng Baijiang Decoction combined with antibiotics in the treatment of pelvic inflammatory disease. Methods A retrospective analysis was performed on patients with pelvic inflammatory disease admitted to Lu’an City Hospital of Traditional Chinese Medicine from December 2016 to July 2020. Using SPSS 22.0 for propensity score matching method, the patients were divided into Erdan Hongteng Baijiang Decoction combined with antimicrobial treatment group(observation group) and single antimicrobial treatment group(control group), with 53 cases in each group. Treatment for both groups lasted for four weeks. The clinical efficacy, treatment course of antibacterial drugs, serum inflammation and immunological index levels were compared between the two groups, and the safety of the two groups was evaluated. Results The total effective rate was 92.5%(49/53) in the observation group and 77.4%(41/53) in the control group, with statistical significance(P<0.05). Compared with before treatment, TCM symptom scores in both groups decreased significantly after treatment(P<0.05);after treatment, TCM symptom scores in the observation group were significantly lower than those in the control group(P<0.01). The average time of antimicrobial use in the observation group was significantly lower than that in the control group(P<0.05). Compared with before treatment, blood IgG levels in the two groups after treatment were significantly lower, and levels of C3 and C4 significantly increased(P<0.05);after treatment, blood IgG levels in the observation group were lower than those in the control group, while levels of C3 and C4 were significantly higher than that of the control group(P<0.01). There were 7 and 6 adverse reactions in the observation group and the control group, respectively. There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05). Conclusion Erdan Hongteng Baijiang Decoction combined with antibiotics can significantly improve the clinical efficacy of pelvic inflammatory disease, adjust and improve the level of inflammatory factors in patients and the immune function of the body.