神经介入溶栓术治疗急性脑梗死的临床疗效及对患者血清NSE、S-100β及神经生长因子的影响

Clinical efficacy of neurointerventional thrombolysis in the treatment of acute cerebral infarction and its effects on serum neuron-specific enolase,S-100β,and nerve growth factor

目的观察神经介入溶栓术治疗急性脑梗死(ACI)的临床疗效,并探讨其对患者血清神经元特异性烯醇化酶(NSE)、S-100β及神经生长因子(NGF)的影响。方法选取2018年1月至2020年6月榆林市第一医院收治的104例ACI患者为研究对象,采用随机数表法将患者分为观察组和对照组各52例,对照组给予静脉溶栓,观察组给予神经介入溶栓术,比较两组患者溶栓治疗后的临床治疗效果,以及溶栓前后的美国国立卫生研究院卒中量表(NIHSS)评分和血清NSE、S-100β、NGF水平。结果观察组患者的临床治疗总有效率为92.31%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);两组患者溶栓后不同时间的NIHSS评分和血清NSE水平均较溶栓前下降,且观察组患者的下降幅度明显大于对照组,差异均有统计学意义(P<0.05);两组患者溶栓后不同时间的血清S-100β水平均较溶栓前下降,差异均有统计学意义(P<0.05);虽然两组患者溶栓后3 d的血清S-100β水平比较差异无统计学意义(P>0.05),但观察组患者溶栓后7 d的血清S-100β水平明显高于对照组,差异有统计学意义(P<0.05);两组患者溶栓后不同时间的血清NGF水平均较溶栓前升高,且观察组升高幅度大于对照组,差异均有统计学意义(P<0.05)。结论神经介入溶栓术治疗ACI能快速降低患者的血清NSE、S-100β水平,提高血清NGF水平,促进患者神经损伤恢复,临床治疗效果显著。

Objective To observe the clinical efficacy of neurointerventional thrombolysis in the treatment of acute cerebral infarction(ACI)and explore its effects on serum neuron-specific enolase(NSE),S-100β,and nerve growth factor(NGF)of patients.Methods A total of 104 patients with ACI who admitted to the First Hospital of Yulin from January 2018 to June 2020 were selected as the research subjects,and they were divided into observation group and control group by random number table method,with 52 patients in each group.The control group was given intravenous thrombolysis,and the observation group was given neurointerventional thrombolysis.The clinical treatment effect after thrombolysis,as well as National Institutes of Health Stroke Scale(NIHSS)score,and levels of serum NSE,S-100β,and NGF before and after thrombolysis were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was significantly higher than that in control group(92.31%vs 75.00%,P<0.05).The NIHSS score and serum NSE level in the two groups at different time after thrombolysis were decreased compared with those before thrombolysis,and the decreases of patients in the observation group were significantly greater than those in control group(P<0.05).Serum S-100βlevel in the two groups at different time after thrombolysis was decreased compared with that before thrombolysis(P<0.05).There was no significant difference in serum S-100βlevel between the two groups at 3 d after thrombolysis(P>0.05),but serum S-100βlevel in the observation group was significantly higher than that in control group at 7 d after thrombolysis(P<0.05).Serum NGF level in the two groups at different time after thrombolysis was increased compared with that before thrombolysis,and the increase in observation group was greater than that in control group(P<0.05).Conclusion Neurointerventional thrombolysis in the treatment of ACI can rapidly reduce the levels of serum NSE and S-100β,increase the level of serum NGF,and promote the recovery of nerve injury,with significant clinical treatment effect.