长链非编码RNA调控不同来源干细胞成骨分化机制的研究进展

Research progress of long non-coding RNA regulation in osteogenic differentiation of stem-cell

肌腱病是世界范围内的常见疾病,无论手术与否,肌腱钙化均是其最常见的并发症之一。然而,肌腱病导致肌腱钙化的发病机制尚不清楚,有证据表明此病理改变可能与肌腱组织中外源性或内源性的干细胞异常成骨分化有关。近年来,长链非编码RNA(lncRNA)参与调控不同来源干细胞成骨分化成为研究热点,这也为解决相应的临床问题提供了一个新方法。本文从lncRNA调控不同来源干细胞成骨分化机制的角度作一综述,为治疗肌腱组织异常成骨分化的发病寻找新的研究方向和靶点。

Tendinopathy is a common disease among the world,and whether repair operation or not,calcification of tendon,is one of the most common complications.Although the mechanism of tendon calcification is unclear,some evidences demonstrated that this pathological change may be related to the abnormal osteogenic differentiation of exogenous or endogenous stem cells in tendon tissue.Recently,lncRNA has become a research hotspot of regulating the osteogenic differentiation of stem-cell in tendon tissue,which also provides a newmethod to solve the corresponding clinical problems.This article reviews the mechanism of lncRNA regulating the osteogenic differentiation of stem cells from different sources,in order to find a new research direction and target for the treatment of abnormal osteogenic differentiation of tendon tissue.