3D打印骨组织工程支架的制备技术

Preparative technique in 3D printing of bone tissue engineering scaffolds

近年来,随着3D打印技术的飞速发展,人们开始通过3D打印技术去不断完善适合不同需求的定制骨组织工程支架。由于组织工程制造的支架是需要植入生物体内的,这就对支架有着极为严苛的要求。3D打印技术作为一种新兴制备骨组织工程支架的技术,其最大的优点是可以依照需求来定制个性化形状、结构,良好的宏微观结构、润湿性、机械强度和细胞反应的新型骨组织工程支架。本文回顾了2014—2019年间对骨组织工程支架的研究,对3D打印骨组织工程支架进行了总结,并且介绍了在多功能骨组织工程支架设计与制作中的理念与研究。

In recent years,with the rapid development of 3D printing technology,people begin improving customized bone tissue scaffolds for different needs through 3D printing technology.Tissue-engineered scaffolds need to be implanted in living organisms,whichmakes them extremely demanding.The biggest advantage of 3D printing technology as emerging technology is:It is possible to create novel bone tissue engineering scaffolds according to the requirement with cus tomized shape,architecture,favorablemacro-micro structure,wettability,mechanical strength and cellular responses.This paper reviews the research progress in 2014—2019 and summarizes the bone tissue engineering scaffold 3D printing technology.It also presents the philosophy and research in the designing and fabrication of bone tissue engineering scaffolds with multiple functions.