低强度迷走神经刺激在心房颤动治疗中的研究进展

Research progress of low-level vagal nerve stimulation in the treatment of atrial fibrillation

心房颤动(房颤)是临床上最常见的心律失常之一,心房炎症和心脏自主神经重构是房颤触发和维持的重要机制,主要表现为心房的炎症因子水平升高、星状神经节或心脏表面神经节丛的神经放电增加。研究表明,低强度迷走神经刺激能够抑制星状神经节或心脏表面神经节丛放电及心房炎症,从而降低房颤负荷。但目前临床上仍缺乏个体化的低强度迷走神经刺激治疗方案,深入探索低强度迷走神经刺激的保护机制有助于该治疗方式的进一步发展。

Atrial fibrillation(AF)is one of the most common arrhythmias in clinical practice.Atrial inflammation and autonomic nerve remodeling are important mechanisms in triggering and maintaining AF,which are mainly manifested by increased levels of inflammatory cytokines in the atrium and increased nerve discharge in stellate ganglion or cardiac surface ganglion plexus.Studies have shown that low level vagal nerve stimulation can reduce atrial fibrillation burden by inhibiting stellate ganglion or cardiac surface ganglion plexus discharge and atrial inflammation.However,there is still a lack of individualized treatment of low level vagal nerve stimulation in clinical practice.Further exploration of the protective mechanism of low level vagal nerve stimulation is conducive to the further development of this treatment.