产前糖皮质激素对新生儿神经系统的影响

Effect of antenatal corticosteroids on neonatal neurodevelopment:a review

妊娠34周内存在早产风险的孕妇应用产前糖皮质激素(antenatal corticosteroid,ACS)可有效降低早产儿呼吸窘迫综合征、脑室内出血和坏死性小肠结肠炎等的发生率。考虑到糖皮质激素可能对新生儿神经系统发育产生不良影响,目前关于妊娠≥34周及有合并症的孕妇应用产前糖皮质激素的意见不一。本文综述了不同孕周和有合并症的孕妇产前应用糖皮质激素对新生儿神经系统并发症的短期和长期影响。

Antenatal corticosteroid administration to women at risk of preterm delivery within 34 gestational weeks can effectively reduce the incidence of respiratory distress syndrome,intraventricular hemorrhage,and necrotizing enterocolitis in preterm infants.Due to concerns that antenatal corticosteroids may impair the development of the newborn's nervous system,there is a controversy regarding the use of antenatal corticosteroids in pregnant women≥34 gestational weeks and those with complications.This article reviews the short-and long-term effects of antenatal corticosteroid administration on the nervous system of neonates born to women at different gestational ages and with comorbidities.More and higher-quality evidence is required for routine application of antenatal corticosteroids in pregnant women≥34 gestational weeks.