摘要
急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)是由弥漫性肺间质及肺泡水肿导致的急性呼吸功能不全。高迁移率族蛋白B1(HMGB1)作为ALI/ARDS炎症进展中重要的晚期炎性因子,可与其细胞表面受体Toll样受体4(TLR4)、晚期糖基化终产物受体(RAGE)等结合,激活下游通路,进而诱导转录多种炎性因子。HMGB1-TLR4/RAGE信号通路复杂,在ALI/ARDS进程中的作用机制尚不明确。本文就HMGB1-TLR4/RAGE信号通路在ALI/ARDS中的研究进展进行综述,以期发现ALI/ARDS的治疗新靶点。
Acute lung iniury(ALI)/acute respiratory distress syndrome(ARDS)is an acute respiratory insufficiency caused by diffuse interstitial and alveolar edema.High-mobility group box 1 protein(HMGB1),as an important late inflammatory factor in the inflammatory progression of ALI/ARDS,can bind to cell surface receptors such as Toll-like receptor 4(TLR4)and receptor for advanced glycation end products(RAGE),activate the downstream pathway,and then induce the transcription of various inflammatory factors.HMGB1-TLR4/RAGE signaling pathway is complex,and the mechanism of action in the ALI/ARDS process is unclear.This paper reviews the research progress of HMGB1-TLR4/RAGE signaling pathway in ALI/ARDS in order to find new therapeutic targets for ALI/ARDS.
作者
秘乐
范绍辉
徐宇
舒小燚
王红嫚
Bi Le;Fan Shaohui;Xu Yu;Shu Xiaoyi;Wang Hongman(Department of Respiratory and Critical Care Medicine,the Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University,Zhuhai 519100,China)
出处
《国际呼吸杂志》
2021年第9期703-708,共6页
International Journal of Respiration
基金
国家自然科学基金(81960023)
贵州省科技合作计划项目(黔科合LH字[2015]7536号)。
关键词
急性肺损伤
呼吸窘迫综合征
成人
高迁移率族蛋白B1
TOLL样受体4
晚期糖基化终产物受体
炎症因子
Acute lung iniury
Respiratory distress syndrome,adult
High-mobility group box 1 protein
Toll-like receptor 4
Receptor for advanced glycation end products
Inflammatory factor
