HIV-1潜在病毒库的研究进展

Research advance on the latent reservoir for HIV-1

尽管应用了ART,HIV-1感染的细胞仍然长期存在,这是治疗HIV-1的主要障碍。晚期感染的记忆性CD4细胞是导致病毒持续存在的主要细胞类型,但一些研究表明,非T细胞也可以作为长期的病毒库。目前利用潜伏期反转剂(LRAs)暴露潜伏的HIV-1和通过免疫效应功能杀死暴露细胞的“激活和杀伤”策略得到越来越多人的关注,而艾滋病功能性治愈又逐渐成为目前艾滋病治疗中的研究热点。本文对体内潜伏HIV的细胞、病毒库的持续机制及治疗策略的研究进展进行综述。

Reservoirs of HIV-1-infected cells persist long-term despite highly active antiretroviral therapy(ART)and represent the main barrier against a cure for HIV-1.Latently-infected memory CD4 cells are the predominant cell compartments responsible for viral persistence,but some studies suggest that non-T cells can also serve as long-term viral reservoirs.The"shock and kill"strategy aiming to expose latent HIV-1 with latency-reversing agents(LRAs)and kill the exposed cells through immune effector functions is currently attracting more attention.The functional cure of AIDS seems to be a hot spot in the current treatment of AIDS.This paper reviews the recent progress of HIV-1 reservoirs on latent cells in vivo,persistence mechanism,and therapy strategies.