变异链球菌与白色念珠菌相互作用机制的研究进展

Research progress on the interaction mechanism between Streptococcus mutans and Candida albicans

口腔微生物之间的相互作用对于口腔微生态平衡的维持以及口腔疾病的发生至关重要。变异链球菌和白色念珠菌分别是口腔的主要致龋细菌和主要致病真菌,研究表明两种微生物之间存在复杂的跨原核生物界-真核生物界相互作用,对临床致病性具有潜在影响。文章将综述变异链球菌和白色念珠菌的相互作用机制以及对致病性的影响,对于将天然产物应用于控制变异链球菌与白色念珠菌的双菌种生物膜及其毒力的探索研究也进行了总结。

The interaction between oral microorganisms is critical for the maintenance of oral microecological balance and the occurrence of oral diseases.Studies have shown that there is a complex interkingdom interaction between the main cariogenic bacteria,Streptococcus mutans,and the main opportunistic pathogenic fungus in the mouth,Candida albicans,which may affect the clinical pathogenicity of each other.In this review,we summarized the influence of the interaction between Streptococcus mutans and Candida albicans on pathogenicity and known mechanisms.The application of natural products to control biofilms of Streptococcus mutans and Candida albicans and the virulence were also summarized.