子宫内膜异位症纤维化发生机制的研究进展

Research progress on the mechanism of fibrosis in endometriosis

子宫内膜异位症(EMs)在组织学上常表现为子宫内膜腺体和间质周围包裹过多致密的纤维组织,这种过度的纤维化会导致患者瘢痕形成、慢性疼痛、不孕等。EMs纤维化的发生机制大多与免疫炎性细胞因子、活化的血小板、巨噬细胞、感觉神经纤维及非编码RNA等多种因素密切相关。文章旨在总结参与EMs纤维化的关键因素及其作用机制,为寻找EMs纤维化新的治疗靶点提供依据。

Endometriosis(EMs)is a commonly seen benign disease,which often histologically manifested as excessive dense fibrous tissue around the glands and stroma of the endometrium.This excessive fibrosis can lead to scar formation,chronic pain,and infertility,etc.The mechanism of EMs fibrosis is mostly closely related to various factors such as immunoinflammatory cytokines,activated platelets,macrophages,sensory nerve fibers and non-coding RNA.This article aims to summarize the key factors involved in EMs fibrosis and their mechanism of action,and provide a basis for finding new therapeutic targets for EMs fibrosis.