基础胰岛素的临床应用及研究进展

Clinical application and research progress of basal insulin preparations

胰岛素是治疗糖尿病的重要手段之一,外周胰岛素尽可能模拟内源性胰岛素作用是胰岛素治疗不断的追求。与早期基础胰岛素相比,新一代基础胰岛素的生物变异度更低,作用时间更长,能有效减少低血糖的发生,改善糖尿病患者预后。本文回顾了基础胰岛素的研究进展,比较了不同基础胰岛素的结构及药物代谢动力学差异,旨在为糖尿病患者的基础胰岛素选择提供参考。

Insulin is one of the most important treatment for diabetes mellitus. It is the continuous pursuit of insulin therapy that peripheral insulin can simulate endogenous insulin action as much as possible. Compared with early basal insulin preparations,new-generation basal insulin has lower biological variability and longer action time,which can effectively reduce the occurrence of hypoglycemia and improve the prognosis of diabetic patients. This paper reviewed the researh progress of basal insulin and compared the structure and pharmacokinetics of different basal insulin,aiming to provide reference for the selection of basal insulin for diabetic patients.