厌氧氨氧化细菌Candidatus Kuenenia stuttgartiensis铁的吸收利用研究进展

Research progress in the uptake and utilization of iron by the anaerobic ammonium-oxidizing bacterium Candidatus Kuenenia stuttgartiensis

铁是影响微生物生长代谢的关键元素,它与蛋白质结合,起催化、氧化还原或调节作用。厌氧氨氧化(ANAMMOX)细菌的生长代谢严重依赖铁,尤其是含铁蛋白。ANAMMOX细菌的厌氧生活方式和厌氧氨氧化体的存在使其对铁代谢的模式不同于其他微生物。弄清ANAMMOX细菌的铁吸收代谢模式,可为获得其纯培养物奠定基础,有利于促进其在环境领域中的应用。在这里,我们将现有铁吸收、利用和代谢的观点、与ANAMMOX细菌的基因组信息和有限的生化生理数据结合起来,提出ANAMMOX细菌可能的铁利用途径,为后续的生理生化研究提供参考。

Iron is a key element that influences microbial growth and metabolism by binding to proteins and acting as a catalyst,redox or regulator.The growth metabolism of anaerobic ammonium-oxidizing(ANAMMOX)bacteria is highly dependent on iron,especially iron-containing proteins.The anaerobic lifestyle of ANAMMOX bacteria and the presence of anammoxosome make their pattern of iron metabolism different from that of other microorganisms.Clarification of the pattern of iron uptake metabolism of ANAMMOX bacteria could provide the basis for obtaining their pure cultures and facilitate their application in the environmental field.Here,we combine existing views on iron uptake,utilization,and metabolism with genomic information and limited biochemical and physiological data of ANAMMOX bacteria to propose possible iron utilization pathways of ANAMMOX bacteria for subsequent physiochemical and biochemical studies.