原发性胆汁性胆管炎肝内小胆管上皮细胞损伤的免疫学机制

Immune mechanism of biliary epithelial cell injury in the small intrahepatic bile ducts in primary biliary cholangitis

原发性胆汁性胆管炎(PBC)是一种遗传和环境因素共同作用的、以肝内小胆管上皮细胞(BEC)凋亡性坏死为特征的慢性自身免疫性肝病。阐述了PBC时B淋巴细胞、巨噬、自然杀伤(NK)、NKT和T淋巴细胞等对BEC的免疫损伤作用,为PBC免疫靶向治疗提供一定的指导意义。

Primary biliary cholangitis(PBC)is a chronic autoimmune liver disease caused by the combined effect of genetic and environmental factors and characterized by the apoptotic necrosis of biliary epithelial cells(BEC)in the small intrahepatic bile ducts.This article describes the effect of B cells,macrophages,natural killer cells,NKT,and T cells on the immune injury of BEC during PBC,so as to provide some guidance for the targeted immune therapy for PBC.