摘要
N6-甲基腺苷(N6-methyladenosine,m6A)甲基化修饰是真核生物RNA最常见的表观修饰方式之一,该方式能够在相关酶共同可逆调节作用下,调控mRNA、LncRNA和miRNA等多种RNA的代谢过程.越来越多针对宫颈癌、卵巢癌、子宫内膜癌等妇科肿瘤的研究取得进展,发现m6 A甲基化在妇科肿瘤的发生发展及预后中具有重要价值.本文就m6 A甲基化修饰的概念、功能、作用机制等在妇科肿瘤最新研究进展作一综述,以期为妇科肿瘤的诊断、治疗、预后及监测提供新依据.
N6-methyladenosine(m6 A) methylation is one of the most common epigenetic modifications of eukaryotic RNA, which can regulate mRNA, lncRNA, miRNA and other RNA metabolic processes under reversible regulation of related enzymes. As increasing progress has been made in studies on gynecologic tumors such as cervical cancer, ovarian cancer and endometrial cancer, it is suggested that m6 A methylation plays an important role in the occurrence, development and prognosis of gynecologic tumors. In this review, the concept, function and mechanism of m6 A methylation in gynecologic tumors are reviewed, hoping to provide a new basis for the diagnosis, treatment, prognosis and monitoring of gynecologic tumors.
作者
王博
马剑
马晓欣
Wang Bo;Ma Jian;Ma Xiaoxin(Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang 110022,Liaoning,China)
出处
《肿瘤预防与治疗》
2021年第5期461-468,共8页
Journal of Cancer Control And Treatment
基金
国家自然科学基金(编号:81872123)
辽宁省“兴辽英才计划”项目资助(编号:XLYC1902003)
中国医科大学2018年学科建设“重大专项建设计划”(编号:3110118029)
盛京自由研究者基金(编号:201601)。
