川崎病冠状动脉病变的手术治疗

Surgical treatment of coronary artery lesions caused by Kawasaki disease

川崎病是一种急性自限性全身血管炎性综合征。该病好发于儿童,主要侵犯全身中小动脉,以冠状动脉最为显著,早期主要表现为冠状动脉扩张、冠状动脉瘤形成,后期随病程进展,形成血栓、内膜增生、钙化,进一步可发展为慢性缺血性心脏病,少数可发生心肌梗死。川崎病已成为发达国家儿童获得性心脏病的首要病因。目前,针对川崎病所致冠状动脉病变的治疗主要有药物治疗和手术治疗,严重者常需要通过手术干预,现就川崎病所致冠状动脉病变的手术治疗方式、适应证和进展作一综述。

Kawasaki disease is an acute self-limiting systemic vasculitis syndrome and usually occurs in children.The small and medium arteries of the whole body are mainly invaded,and marked with coronary arteries.Coronary artery dilation and aneurysm formation mainly occur in the early period.Thrombi,intimal hyperplasia,and calcification could be formed during the later period.Consequently,sometimes,it develops intochronicischemic cardiopathy or myocardial infarction.In that,Kawasaki disease has become the leading cause of acquired heart disease for children in developed countries.Presently,the treatment of coronary artery lesions caused by Kawasaki disease includes drug therapy,and interventional and surgical treatment.However,medications usually fail to solve severe coronary conditions,and only interventional and surgical treatment can we choose.Therefore,the development and indications of interventional and surgical treatment of coronary artery lesions caused by Kawasaki disease were reviewed in this article.