富血小板血浆应用于踝关节大骨节病的临床研究

Clinical study of PRP in ankle Kaschin-Beck disease

目的探讨富血小板血浆(platelet rich plasma, PRP)应用于大骨节病中踝关节炎的临床研究。方法选择我院门诊就诊的40例大骨节病踝关节炎患者,年龄50~60岁,采用随机数字表法将患者分富血小板血浆组(PRP组)20例和玻璃酸钠组(HA组)20例,分别于0、2、4、8周进行踝关节腔内注射,在治疗前和治疗后采用美国足与踝关节协会踝与后足功能评分(ankle hind foot scale, AOFAS)及视觉模拟评分(visval analogue scale, VAS)。结果 PRP治疗组和HA对照组,在0、2、4、8周后,VAS评分低于治疗前,AOFAS评分高于治疗前,差异有统计学意义(P<0.05)。结论 PRP与玻璃酸钠相比,两者治疗效果差异性不大,可以同玻璃酸钠等传统方法共同作为治疗踝关节大骨节病的方法。

Objective To investigate the clinical study of PRP in ankle arthritis in Kashin-Beck disease. Methods Fourty patients with Kashin-Beck disease ankle arthritis, aged 50~60 years, were randomly divided into platelet-rich plasma group(n=20) and sodium hyaluronate group(n=20). The patients were injected into ankle joint cavity at 0, 2, 4 and 8 weeks, respectively. Before and after treatment, the ankle hind foot scale(AOFAS) and visual analogue scale(VAS) were used. Results PRP group and HA control group, at 0, 2, 4, 8 weeks later, the VAS score was lower than that before treatment, and the AOFAS score was higher than that before treatment, the difference was statistically significant(P<0.05). Conclusion Compared with sodium hyaluronate, PRP and sodium hyaluronate have little difference in treatment effect, which can be used as a common method for the treatment of ankle Kashin Beck disease with sodium hyaluronate and other traditional methods.