长链非编码RNAs与缺血性脑卒中

Long non-coding RNAs and ischemic stroke

缺血性脑卒中是世界范围内导致死亡和残疾的主要原因之一。科学家们一直致力于阐明其中的细胞和分子病理生理过程。长链非编码RNAs(long non-coding RNAs,lncRNAs)在许多疾病中发挥重要作用。近年来,在缺血性脑卒中患者和脑缺血动物模型上发现了大量异常表达的lncRNAs。这些lncRNAs参与促进脑缺血后的细胞凋亡、血管形成、炎症反应和细胞死亡。上述发现可能有助于阐明lncRNAs在缺血性卒中的作用和机制。进一步探究lncRNAs在正常和病理条件下的功能和机制,可能有助于寻找缺血性卒中的生物标志物和新的治疗靶点。

Ischemic stroke is one of the leading causes of mortality and disability worldwide. Scientists have been trying to clarify the cellular and molecular pathophysiological processes. Long non-coding RNAs(lncRNAs) play an important role in a lot of diseases.Recent studies have found that there were a bulk of differentially expressed lncRNAs in both ischemic stroke patients and animal models. They participated in regulating cell apoptosis,angiogenesis,inflammation,and cell death. Those investigations may help to elucidate the mechanisms and functions of lncRNAs in ischemic stroke,which may provide new strategies for seeking new biomarkers and therapeutic targets of ischemic stroke.