重组人生长激素给药系统的研究进展

Research progress of recombinant human growth hormone delivery systems

重组人生长激素(rhGH)是治疗各种生长激素缺乏症及并发症的首选药物,但临床上需长期频繁注射给药,实现rhGH长效化和改变给药途径可显著提高患者依从性,具有重要的研究价值。本文针对近年来rhGH长效化制剂和非注射给药途径的类型、有效性及开发现状进行了综述,主要介绍了利用化学修饰、构建融合蛋白、构建缓释微球等rhGH长效化方法以及经皮给药、肺部给药、鼻腔黏膜给药等rhGH非注射给药途径的研究现状和最新进展,分析了各类rhGH给药系统在应用方面的潜在问题,以期使读者对该领域的研究状况有更全面、更清楚的了解;并指出了该研究领域未来的发展方向,提出了将rhGH长效化与非注射给药途径合理结合应是将来实现rh GH高效递送的重要研究方向,以期为进一步开发安全有效的rhGH新型给药系统提供参考。

Recombinant human growth hormone(rhGH)is the first choice to treat various growth hormone deficiencies and complications.But the rhGH requires long-term and frequent injection clinically.Long-acting rhGH preparations and non-injection administration routes can significantly increase patient compliance.In this paper,the types,effectiveness and development status of long-acting rhGH preparations and non-injection administration routes were reviewed.The research status and latest progress of rhGH long-acting methods(such as chemical modification,construction of fusion proteins,construction of sustained-release microspheres)and non-injection routes of rhGH(such as transdermal,pulmonary,nasal administrations)were introduced.The potential application problems of these rhGH delivery systems were analyzed,so that readers can have a more comprehensive and clear understanding of the research status in this field.The future development direction of this field was also proposed,that the rational combination of long-acting and non-injection administration would be an important research direction to achieve high-efficiency delivery of rhGH in the future.This paper provides a reference for the further development of a new safe and effective rhGH drug delivery system.