腹源性脓毒症早期CRRT干预治疗的临床研究

Clinical Study of Early CRRT Intervention Treatment of Abdominal Sepsis

目的:探讨腹源性脓毒症早期CRRT干预治疗的临床效果。方法:以86例腹源性脓毒症患者为观察对象,均选取自2018年1月—2020年10月时间段,采用单双号抽签的方式分组实施研究,其中43例抽取到单号的患者纳入对照组,采用常规抗感染及脏器支持治疗,剩余43例抽取到双号的患者纳入观察组,实施早期CRRT干预治疗,对比两组患者治疗前后APACHEⅡ评分、SOFA评分、血流动力学指标与生化指标变化情况。结果:观察组治疗后的APACHEⅡ评分及SOFA评分均低于治疗前及对照组(P<0.05);两组患者MAP治疗后显著提升(P<0.05),但组间对比无显著差异(P>0.05);观察组治疗后的HR显著低于治疗前及对照组(P<0.05);两组治疗前后CVP无显著差异(P>0.05);观察组治疗后的SCr、BUN、PCT及hs-CRP指标均低于治疗前及对照组(P<0.05)。结论:针对腹源性脓毒症患者,早期实施CRRT干预治疗,有助于及时清除患者体内的代谢废物,维持血流动力学的稳定性,改善其生化指标,维持其内环境的稳定性,缓解其病情危重程度。

Objective:To explore the clinical effects of early CRRT intervention in abdominal sepsis.Methods:86 patients with abdominal sepsis were selected as the observation object,all of which were selected from January 2018 to October 2020,and the study was carried out in groups using odd and even numbers,43 of which were drawn to single numbers Patients were included in the control group and received conventional anti-infection and organ support treatment.The remaining 43 patients with double numbers were included in the observation group and received early CRRT intervention.The APACHEⅡ score,SOFA score,and blood flow of the two groups were compared before and after treatment.Changes in dynamics and biochemical indicators.Results:After treatment,the APACHEⅡ score and SOFA score of the observation group were lower than those before treatment and the control group(P<0.05);MAP of the two groups of patients increased significantly after treatment(P<0.05),but there was no significant difference between the groups(P>0.05);HR after treatment in the observation group was significantly lower than that before treatment and the control group(P<0.05);there was no significant difference in CVP between the two groups before and after treatment(P>0.05);SCr,BUN,PCT and hs in the observation group after treatment-CRP indicators were lower than those before treatment and the control group(P<0.05).Conclusion:For patients with abdominal sepsis,early implementation of CRRT intervention therapy can help to clear the metabolic waste in the patients in time,maintain the stability of hemodynamics,improve their biochemical indicators,and maintain the stability of their internal environment.Relieve the severity of his illness.