栀子金花丸联合西地碘含片治疗复发性口腔溃疡的临床研究

Clinical Study of Zhizi Jinhua Pills Combined with Cydiodine Buccal Tablets in the Treatment of Recurrent Oral Ulcers

目的:探讨栀子金花丸联合西地碘含片治疗复发性口腔溃疡(recurrent oral ulcer,ROU)的临床疗效。方法:选取2017年7月至2019年6月淮安市口腔医院收治的ROU患者102例,将上述患者按照随机数字表法分为对照组和研究组,每组51例。对照组患者予以西地碘含片治疗,研究组患者在对照组的基础上联合栀子金花丸治疗,两组患者均治疗14 d。观察两组患者的临床疗效及不良反应发生情况,治疗前后炎症因子及中医证候积分;随访6个月记录患者复发情况。结果:研究组患者灼痛消失时间、溃疡面愈合时间均明显短于对照组,差异均有统计学意义(P<0.05)。研究组患者的临床总有效率为92.16%(47/51),明显高于对照组的76.47%(39/51),差异有统计学意义(P<0.05)。两组患者治疗后白细胞介素6(IL-6)、超敏C反应蛋白(hs-CRP)及肿瘤坏死因子α(TNF-α)水平较治疗前明显降低,且研究组患者明显低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后溃疡疼痛、烧灼感、溃疡渗出、溃疡面积、溃疡充血、口干口渴、水肿及便干便秘等证候积分均较治疗前明显降低,且研究组患者明显低于对照组,差异均有统计学意义(P<0.05)。研究组患者的复发率为9.80%(5/51),明显低于对照组的27.45%(14/51),差异有统计学意义(P<0.05)。对照组、研究组患者的不良反应发生率分别为3.92%(2/51)、5.88%(3/51),两组比较,差异无统计学意义(P>0.05)。结论:采用栀子金花丸联合西地碘含片治疗ROU,能迅速改善患者的临床症状,有效控制病情,降低炎症因子水平,减少溃疡复发,具有较高的临床应用价值。

OBJECTIVE:To probe into the clinical efficacy of Zhizi Jinhua pills combined with Cydiodine buccal tablets in the treatment of recurrent oral ulcers(ROU).METHODS:Totally 102 patients with ROU admitted into Huai’an Stomatological Hospital from Jul.2017 to Jun.2019 were extracted to be divided into the control group and the research group via the random number table,with 51 cases in each group.The control group was treated with Cydiodine buccal tablets,while the research group received Zhizi Jinhua pills on the basis of the control group.Both groups were treated for 14 d.Clinical efficacy,adverse drug reactions,inflammatory factors and traditional Chinese medicine syndrome scores before and after treatment were observed in two groups.Recurrence was recorded at 6 months of follow-up.RESULTS:The disappearance time of burning pain and healing time of ulcer surface in the research group were shorter than those in the control group,with statistically significant difference(P<0.05).The total clinical efficiency in the research group was 92.16%(47/51),significantly higher than 76.47%(39/51)in the control group,the difference was statistically significant(P<0.05).Compared with before treatment,the levels of interleukin-6(IL-6),high sensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)in two groups decreased significantly after treatment,and the research group was lower than the control group,with statistically significant difference(P<0.05).After treatment,the scores of ulcer pain,burning sensation,ulcer exudation,ulcer area,ulcer hyperemia,thirst,edema and constipation decreased significantly in two groups,and the scores in the research group were lower than those in the control group,with statistically significant difference(P<0.05).The recurrence rate of the research group was 9.80%(5/51),significantly lower than 27.45%(14/51)in the control group,the difference was statistically significant(P<0.05).The incidences of adverse drug reactions in the control group and the study group were respectively 3.92%(2/51)and 5.88%(3/51),the difference was not statistically significant(P>0.05).CONCLUSIONS:The application of Zhizi Jinhua pills combined with Cydiodine buccal tablets in the treatment of recurrent oral ulcer can rapidly improve the clinical symptoms of patients,effectively control the conditions,reduce the levels of inflammatory factors and the recurrence of ulcer,which has higher clinical application value.