CD247基因多态性与1型糖尿病的病例对照研究

A case-control study on the correlation between CD247 gene polymorphism and type 1 diabetes mellitus

采取294例中国汉族1型糖尿病患者与199例对照者外周静脉血,提取DNA,对CD247基因多态性位点rs17534481、rs12095738、rs2988276、rs6668182进行检测。结果显示,CD247基因的多态性位点rs17534481与中国汉族人群T1DM发病相关,该位点等位基因T是1型糖尿病发生的保护性因素(OR=0.667,P=0.037)。位点rs12095738、rs2988276、rs6668182的基因型频率及等位基因频率在两组中分布的差异无统计学意义(P>0.05)。

The blood samples of 294 Chinese Han patients with type 1 diabetes mellitus(T1DM)and 199 controls were collected and their genomic DNAs were extracted.The single nucleotide polymorphisms rs17534481,rs12095738,rs2988276,and rs6668182 of CD247 gene were detected.The results showed that rs17534481 polymorphism of CD247 gene was associated with T1DM in Chinese Han population,and T allele was a protective factor for type 1 diabetes mellitus(OR=0.667,P=0.037).There was no significant difference in genotype frequency and allele frequency of rs12095738,rs2988276,and rs6668182 between type 1 diabetes group and control group(P>0.05).