摘要
目的通过分析新疆地区天疱疮患者合并脂代谢异常的临床特征,探讨天疱疮与血脂代谢异常之间的相关性。方法收集2010年10月-2020年10月在本科初次住院治疗的122例天疱疮患者及同期在本院体检中心体检的健康人群122例作为研究对象。两组在性别、年龄之间差异无统计学意义(P>0.05),具有可比性。收集两组所有研究对象的身高、体重、血压、血糖、血清钙和血脂相关指标等数据,并对相关因素进行Logistic回归分析。结果观察组患者的维吾尔族的比例、身体质量指数(BMI)、吸烟比例、甘油三酯(TG)和血清总胆固醇(CHOL)水平高于对照组,血清钙(Ca^(2+))浓度、高密度脂蛋白胆固醇(HDL-C)水平低于对照组,差异有统计学意义(P<0.05)。两组的年龄、性别、糖尿病、高血压比例和低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05)。TG水平(OR=1.44)是发生天疱疮的危险因素。不同疾病严重程度的血脂水平比较,差异无统计学意义(P>0.05)。抗桥粒芯糖蛋白抗体1、3(Dsg1、Dsg3)和血脂指标HDL-C、LDL-C、TG、CHOL之间均无显著相关性(P>0.05)。结论天疱疮患者和健康对照组的血脂水平差异有统计学意义,血脂异常可能增加天疱疮的发病风险。
Objective By analyzing the clinical characteristics of pemphigus patients with abnormal lipid metabolism in Xinjiang, the correlation between pemphigus and abnormal lipid metabolism was explored.Methods A total of 122 patients with pemphigus who received initial hospitalization in our department from October 2010 to October 2020 and 122 healthy people who received physical examination in the physical examination center of our hospital during the same period were collected as the research objects.There was no statistical difference(P>0.05) between the two groups in gender and age, indicating comparability.Data related to height, weight, blood pressure, blood glucose, serum calcium and blood lipid of all subjects in the two groups were collected, and relevant factors were analyzed by Logistic regression.Results Uygur proportion, body mass index(BMI),smoking proportion, triglyceride(TG) and total serum cholesterol(CHOL) level in the observation group were higher than those in the control group, and serum Ca^(2+) concentration and high-density lipoproteincholesterol(HDL-C) level were lower than those in the control group, with statistically significant differences(P<0.05).There were no significant differences in age, gender, diabetes, hypertension and low-density lipoprotein cholesterol(LDL-C) level between the two groups(P>0.05).TG level(OR=1.44) was a risk factor for pemphigus.There was no significant difference in blood lipid levels between different disease severity(P>0.05).There was no significant correlation between Dsg1,Dsg3 and blood lipid indexes such as HDL-C,LDL-C,TG and CHOL(P>0.05).Conclusion There were statistically significant differences in blood lipid levels between pemphigus patients and healthy controls, and dyslipidemia may increase the risk of pemphigus.
作者
胡凤侠
梁俊琴
毛丽旦
凯丽比努尔·阿卜力克木
王倩
康晓静
HU Fengxia;LIANG Junqin;MAO Lidan;Kailibinuer Abulikemu;WANG Qian;KANG Xiaojing(Department of Dermatology and Venereology,Pepole's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Key Laboratory of Dermatology Research,Urumqi 830001,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2021年第6期638-642,共5页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金地区项目(81960564)。
关键词
天疱疮
血脂异常
血脂
脂代谢
Pemphigus
Dyslipidemia
Serum lipid
Lipid metabolism