摘要
杀伤细胞免疫球蛋白样受体(KIR)定位于19号染色体白细胞受体复合物(LRC)100~200 kb区域。在功能上KIR分为抑制性与活化性受体,主要表达在自然杀伤(NK)细胞表面。肿瘤细胞可通过下调细胞表面HLA分子的表达,躲避NK细胞的杀伤作用。KIR分子则通过与人类白细胞抗原(HLA)分子结合传导抑制性与活化性信号,调节NK细胞对肿瘤细胞的杀伤作用。近年来KIR及其对肿瘤的免疫调节作用逐渐成为研究的热点。本文回顾了KIR与不同肿瘤的相关性,尤其是与我国两广地区高发肿瘤鼻咽癌(NPC)相关性的研究进展。
The killer cell immunoglobulin-like receptor(KIR) is located in 100-200 kb region of the leukocyte receptor complex(LRC) on chromosome 19. KIR, mainly expresses on the surface of natural killer(NK) cells, is divided into inhibitory and activated receptor in function. Tumor cells could evade the killing of NK cells by regulating down the expression of HLA molecules on the cell surface. KIR molecules regulate the killing effect of NK cells by combining with human leukocyte antigen(HLA) to conduct inhibitory and active signals. In recent years, KIR and its immune regulation on tumors have become a research hotspot. The article reviews the research progress of KIR and its association with tumors, especially the correlation between KIR and high incidence of nasopharyngeal carcinoma(NPC) in Guangdong and Guangxi of China.
作者
蒋雪梦
汤敏中
JIANG Xuemeng;TANG Minzhong(Guilin Medical College,Guilin 541000,China;Department of Medical Laboratory,Wuzhou Red Cross Hospital)
出处
《中国输血杂志》
CAS
2021年第5期556-560,共5页
Chinese Journal of Blood Transfusion
基金
国家自然科研基金项目(81860503)
梧州市科技计划项目(201501036)。
关键词
杀伤免疫球蛋白样受体
人类白细胞抗原分子
自然杀伤细胞
肿瘤
鼻咽癌
killer cell immunoglobulin-like receptor
human leukocyte antigen
natural killer cells
tumor
nasopharyngeal carcinoma
