盐酸米诺环素软膏和替硝唑局部用药治疗牙周炎的有效性及价值探讨

Discussion on effectiveness and value of topical medication of minocycline hydrochloride ointment and tinidazole in the treatment of periodontitis

目的探究盐酸米诺环素软膏和替硝唑局部用药治疗牙周炎的有效性及价值。方法100例牙周炎患者,随机分为观察组和对照组,每组50例。观察组患者给予盐酸米诺环素软膏和替硝唑局部用药治疗,对照组患者给予替硝唑局部用药治疗。对比两组治疗前后牙周指标[牙周探诊深度(PPD)、牙龈指数(GI)、牙周附着水平(PAL)、牙菌斑指数(PLI)],龈沟液白细胞介素-10(IL-10)和转化生长因子-β(TGF-β)水平,外周血辅助性T细胞17(Th17)和调节性T细胞(Treg)水平,不良反应发生情况。结果治疗后,两组PPD、GI、PAL、PLI均较本组治疗前改善,且观察组PPD(4.02±1.02)mm、GI(0.72±0.05)分、PAL(6.22±1.45)mm、PLI(0.72±0.52)分优于对照组的(4.78±1.53)mm、(1.45±0.41)分、(7.78±1.25)mm、(1.15±0.21)分,差异具有统计学意义(P<0.05)。治疗后,两组龈沟液IL-10、TGF-β水平均高于本组治疗前,且观察组高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组外周血Th17、Treg水平均低于本组治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为4.00%,低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论盐酸米诺环素软膏和替硝唑局部用药治疗牙周炎效果显著,且不良反应少,值得临床研究和推广。

Objective To investigate the effectiveness and value of topical medication of minocycline hydrochloride ointment and tinidazole in the treatment of periodontitis.Methods A total of 100 patients with periodontitis were randomly divided into observation group and control group,with 50 cases in each group.The observation group was treated with topical medication of minocycline hydrochloride ointment and tinidazole,and the control group was treated with tinidazole.The periodontal indexes[periodontal probing depth(PPD),gingival index(GI),periodontal attachment level(PAL),dental plaque index(PLI)],gingival crevicular fluid interleukin-10(IL-10),transforming growth factor-β(TGF-β),peripheral blood helper T cell 17(Th17)and regulatory T cells(Treg)before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of PPD,GI,PAL and PLI of the two groups were better than those before treatment,and the PPD(4.02±1.02)mm,GI(0.72±0.05)points,PAL(6.22±1.45)mm and PLI(0.72±0.52)points of the observation group were better than(4.78±1.53)mm,(1.45±0.41)points,(7.78±1.25)mm and(1.15±0.21)points of the control group.All the difference was statistically significant(P<0.05).After treatment,the gingival crevicular fluid IL-10 and TGF-βof the two groups were higher than those before treatment,and the observation group was higher than the control group.All the difference was statistically significant(P<0.05).After treatment,the peripheral blood Th17 and Treg of the two groups were lower than those before treatment,and the observation group was lower than the control group.All the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 4.00%was lower than 20.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Topical medication of minocycline hydrochloride ointment and tinidazole shows significant effect on periodontitis,and the adverse reactions are low,which is worthy of clinical research and promotion.