血、尿生化指标检测在老年原发性高血压患者早期肾损伤诊断中的意义

Significance of blood and urine biochemical indicators in the diagnosis of early renal injury in elderly patients with essential hypertension

目的探讨血、尿生化指标检测在老年原发性高血压患者早期肾损伤诊断中的价值。方法选取200例老年原发性高血压患者,根据内生肌酐清除率分为无肾病组(≥80 ml/min,86例)与肾病组(<80 ml/min,114例);同时选取同期接受体检的80例健康老年人作为对照组。三组研究对象均接受血、尿生化指标检测,比较三组血C反应蛋白(CRP)、肌酐(Cr)、尿酸(UA)、尿素氮(BUN)、α_(1)-微球蛋白(α_(1)-MG)、β_(2)-微球蛋白(β_(2)-MG)水平及尿微量白蛋白(MA)、α_(1)-MG、β_(2)-MG水平。结果肾病组血CRP、Cr、UA、BUN、α_(1)-MG、β_(2)-MG水平均高于无肾病组与对照组,差异有统计学意义(P<0.05);无肾病组血CRP、UA、α_(1)-MG水平均高于对照组,差异有统计学意义(P<0.05)。肾病组尿MA(64.17±21.30)mg/L、α_(1)-MG(40.58±12.47)mg/L、β_(2)-MG(0.82±0.24)mg/L均高于无肾病组的(15.70±5.21)、(22.68±6.32)、(0.21±0.08)mg/L及对照组的(12.46±4.25)、(10.42±2.88)、(0.18±0.06)mg/L,差异有统计学意义(P<0.05);无肾病组尿α_(1)-MG水平高于对照组,差异有统计学意义(P<0.05)。结论血、尿生化指标检测在老年原发性高血压患者早期肾损伤诊断中具备良好应用价值,其中血CRP、UA、血与尿α_(1)-MG水平可为早期肾损伤的发生提供参考。

Objective To discuss the value of blood and urine biochemical indicators in the diagnosis of early renal injury in elderly patients with essential hypertension.Methods A total of 200 elderly patients with essential hypertension were divided into no-nephropathy group(≥80 ml/min,86 cases)and nephropathy group(<80 ml/min,114 cases)according to endogenous creatinine clearance rate.At the same time,80 healthy elderly people who underwent physical examination during the same period were selected as the control group.All three groups were tested for blood and urine biochemical indicators.The C-reactive protein(CRP),creatinine(Cr),uric acid(UA),blood urea nitrogen(BUN),α_(1)-microglobulin(α_(1)-MG),β_(2)-microglobulin(β_(2)-MG)levels and urinary microalbumin(MA),α_(1)-MG,β_(2)-MG levels of three groups were compared.Results The levels of CRP,Cr,UA,BUN,α_(1)-MG andβ_(2)-MG of nephropathy group were higher than those of non-nephropathy group and control group,and the difference was statistically significant(P<0.05).The levels of CRP,UA,α_(1)-MG of non-nephropathy group were higher than those of the control group,and the difference was statistically significant(P<0.05).The MA(64.17±21.30)mg/L,α_(1)-MG(40.58±12.47)mg/L,β_(2)-MG(0.82±0.24)mg/L of nephropathy group were higher than non-nephropathy group[(15.70±5.21),(22.68±6.32),(0.21±0.08)mg/L]and control group[(12.46±4.25),(10.42±2.88),(0.18±0.06)mg/L],and the difference was statistically significant(P<0.05).Theα_(1)-MG of non-nephropathy group was higher than that of control group,and the difference was statistically significant(P<0.05).Conclusion The blood and urine biochemical indexes has good practical value in the diagnosis of early renal injury in elderly patients with essential hypertension.The levels of blood CRP,UA,blood and urineα_(1)-MG can provide references for the occurrence of early renal injury.