利培酮联合齐拉西酮治疗精神分裂症后抑郁的疗效及对患者认知功能、生活质量的影响研究

Study the effect of risperidone combined with ziprasidone in the treatment of post-schizophrenia depression and its influence on cognitive function and quality of life

目的分析利培酮联合齐拉西酮治疗精神分裂症后抑郁的效果及对患者认知功能和生活质量的影响。方法300例精神分裂症后抑郁患者,依据平行对照法分为对照组和观察组,各150例。对照组采用利培酮治疗,观察组采用利培酮联合齐拉西酮治疗。对比两组患者的治疗效果、认知功能评分、生活质量评分及不良反应发生情况。结果观察组治疗总有效率94.00%高于对照组的86.67%,差异具有统计学意义(P<0.05)。治疗后,观察组认知功能评分(70.25±6.78)分高于对照组的(61.32±5.69)分,差异具有统计学意义(P<0.05)。治疗前,两组生理职能、生理功能、情感职能、社会功能、精神健康、躯体疼痛、活力和总体健康评分比较,差异均无统计学意义(P>0.05);治疗后,观察组生理职能、生理功能、情感职能、社会功能、精神健康、躯体疼痛、活力和总体健康评分均高于对照组,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论利培酮联合齐拉西酮治疗精神分裂症后抑郁的效果明显,其有助于患者认知功能和生活质量的提高,值得临床推广。

Objective To analyze the effect of risperidone combined with ziprasidone in the treatment of post-schizophrenia depression and its influence on cognitive function and quality of life.Methods A total of 300 cases of post-schizophrenia depression were divided into control group and observation group according to parallel comparison methods,with 150 cases in each group.The control group was treated with risperidone,and the observation group was treated with risperidone combined with ziprasidone.The therapeutic effect,cognitive function score,quality of life score,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 94.00%of the observation group was higher than 86.67%of the control group,and the difference was statistically significant(P<0.05).After treatment,the cognitive function score(70.25±6.78)points of the observation group was higher than(61.32±5.69)points of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in physiological function,physiological function,emotional function,social function,mental health,physical pain,vitality and overall health score between the two groups(P>0.05).After treatment,the physiological function,physiological function,emotional function,social function,mental health,physical pain,vitality and overall health score of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Combination of risperidone and ziprasidone shows obvious effect on postschizophrenia depression,and it helps improve the cognitive function and quality of life.It is worthy of clinical promotion.