摘要
建立科学的中药质量评价体系是保障中药国际化、产业化的关键,通过中药有效性-物质基础-质量控制关联链辨识质量标志成分,将化学物质与临床疗效关联,以此评价中药有效性、安全性,实现中药整体质量评价。从中药质量评价体系发展历程出发,对围绕中药性状的传统质量评价模式及活性成分的现代质量评价模式进行分析,基于质量标志物(quality marker,Q-Marker)与多学科内容有机结合,探讨Q-Marker质量评价模式的建立,提出创新方法导入中药质量评价的发展趋势。
Establishing a scientific quality evaluation system of traditional Chinese medicine(TCM)is the key to guarantee the internationalization and industrialization of traditional Chinese medicine.It is required to identify the quality marker components through the effectiveness-material basis-quality control chain of TCM,and the chemical substances are associated with clinical efficacy,so as to evaluate the effectiveness and safety of TCM and realize the overall quality evaluation of TCM.Starting from the development process of the quality evaluation system of TCM,the traditional quality evaluation model centering on the characteristics and the modern quality evaluation model of the active ingredients were analyzed.Based on the organic combination of Q-marker and multidisciplinary content,an establishment of quality evaluation model was discussed,and the development trend of quality evaluation of TCM was put forward based on the introduction of innovative methods.
作者
陈丽华
肖发林
黄诗雨
朱卫丰
管咏梅
应鹏云
吕志豪
CHEN Li-hua;XIAO Fa-lin;HUANG Shi-yu;ZHU Wei-feng;GUAN Yong-mei;YING Peng-yun;LYU Zhi-hao(Key Laboratory of Modem Preparation of Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第9期2541-2547,共7页
Chinese Traditional and Herbal Drugs
基金
国家创新方法专项(2020IM010500)。
关键词
质量评价
中药
质量标志物
研究思路
创新发展
quality evaluation
Chinese materia medica
quality marker
research ideas
innovation development