基于化学成分特有性的质量标志物发现策略及应用

Discovery strategy and application of quality markers of traditional Chinese medicine based on component specificity

中药质量标志物(quality marker,Q-Marker)是中药质量控制的新概念。按照中药质量标志物确定的"五原则",其中的"特有性"是确定中药Q-Marker的重要依据之一。目前的中药质量评价方法或质量标准存在质量控制指标专属性差、常见以同一指标成分评价不同药材的质量而难以反映不同药材的质量特质的问题。以Q-Marker核心概念为统领,结合化学成分特有性的理论依据,提出基于成分"特有性"的中药Q-Marker研究路径,有利于提升中药质量,为中药标准化建设提供新的思路,促进中药产业的健康发展。

Q-Marker is a new concept of quality control of traditional Chinese medicine(TCM).According to the"five principles"for the determination of Q-marker of TCM,"specificity"is one of the vital basis for confirming the Q-marker of TCM.Nowadays,the poor specificity of the quality control and the evaluation by identical index components for diverse herbs existed in the current quality evaluation method of TCM,which is difficult to embody the qualitative characteristics of different herbs.Focused on the core concept of Q-marker,this paper puts forward a research thought for Q-marker based on component specificity combined with the theoretical basis of chemical component specificity,which is beneficial for the quality enhancement of TCM and provides a new idea for the standardized construction of TCM,so as to promote the healthy development of TCM industry.