红芪化学成分和药理作用研究进展及质量标志物(Q-Marker)的预测分析

Research progress on chemical constituents and pharmacological effects of Hedysari Radix and predictive analysis on quality markers

红芪为甘肃的大宗药材,主要含有红芪多糖类、黄酮类、苯丙素类、三萜及甾体类化合物、微量元素、生物碱类、有机酸类等化学成分。其药理研究主要集中在抗肿瘤、抗炎、抗氧化、免疫调节、降糖、调脂、降压等方面。通过文献检索,梳理和总结了近几年国内外红芪化学成分及其药理作用研究,从传统功效、药性、不同加工、化学成分可测等多方面对其质量标志物(quality marker,Q-Marker)进行了预测分析,最终预测了红芪多糖、毛蕊异黄酮、毛蕊异黄酮苷、芒柄花素、芒柄花苷、美迪紫檀素、γ氨基丁酸等化学成分,以期为红芪质量评价体系的建立及开发利用提供参考。

Hongqi(Hedysari Radix)is a major medicinal material in Gansu Province.It mainly contains polysaccharides,flavonoids,phenylpropanoids,triterpenoids and steroids,trace elements,alkaloids,organic acids and other chemical components.Its pharmacological research mainly focused on anti-tumor,anti-inflammatory,antioxidant,immunomodulatory,hypoglycemic,lipidlowering,and antihypertensive effects.By literature retrieval,the research on chemical constituents and pharmacological effects of Hedysari Radix at home and abroad in recent years are reviewed and summarized in this paper.The quality markers(Q-Marker)of Hedysari Radix from the aspects of traditional efficacy,drug properties,different processing,and chemical components measurability are predicted and analyzed,Finally,the chemical components of Hedysari Radix polysaccharide,calycosin,campanulin,formononetin,ononin,medicarpin,andγ-aminobutyric acid were predicted,so as to provide reference for establishment and development of quality evaluation system of Hedysari Radix.