不同抗生素治疗方案对婴幼儿肠道微生态和外周血T淋巴细胞亚群的影响

Comparison of the effect of different antibiotic treatment regimens on intestinal microecology and peripheral blood T lymphocyte subsets in infants

目的探讨比较不同抗生素治疗方案对婴幼儿肠道微生态和外周血T淋巴细胞亚群的影响。方法选取2019年1—12月杭州市富阳区妇幼保健院72例应用抗生素治疗的婴幼儿为观察组,另选取同院同时期的24例未应用抗生素治疗的健康婴幼儿为对照组。比较2组婴幼儿的肠道微生态和外周血T淋巴细胞亚群结果,同时比较观察组中应用不同抗生素治疗对以上指标的影响。结果观察组与对照组的肠道微生态情况、外周血T淋巴细胞亚群比较差异均有统计学意义(均P<0.05);观察组中β-内酰胺类联合非β-内酰胺类抗生素治疗者的乳酸杆菌及双歧杆菌水平低于单用β-内酰胺类与非β-内酰胺类者(均P<0.05);观察组中β-内酰胺类联合非β-内酰胺类抗生素治疗者的肠道菌群正常情况为8.33%,显著低于单用β-内酰胺类者(45.83%)与非β-内酰胺类者(58.33%),差异有统计学意义(均P<0.05);观察组中β-内酰胺类联合非β-内酰胺类抗生素治疗者的CD8+、CD3+、CD4+明显低于单用β-内酰胺类与非β-内酰胺类者,差异有统计学意义(均P<0.05)。结论抗生素β-内酰胺类联合非β-内酰胺类的治疗方案对婴幼儿肠道微生态和外周血T淋巴细胞亚群的影响较大。

Objective To investigate the effect of different antibiotic treatment regimens on intestinal microecology and peripheral blood T lymphocyte subsets in infants. Methods A total of 72 infants treated with antibiotics in the Maternal and Child Health Hospital of Fuyang District, Hangzhou from January 2019 to December 2019 were selected as the observation group. Meanwhile, 24 healthy infants not administered with antibiotics were selected as the control group. The intestinal microecology and peripheral blood T lymphocyte subsets in both groups were compared. Additionally, the effect of different antibiotic treatment regimens on the above indices in the observation group was compared. Results Differences in intestinal microecology and peripheral blood T lymphocyte subsets between the observation and control groups were significant(all P<0.05). In the observation group, levels of lactobacilli and bifidobacteria were lower in infants treated with β-lactams combined with non-β-lactams antibiotics than those treated with β-lactams or non-β-lactams alone(all P<0.05). The proportion of normal intestinal microflora in infants treated with β-lactams combined with non-β-lactams antibiotics(8.33%) was significantly lower than that in those treated with β-lactams(58.33%) or non-β-lactams(45.83%) alone(all P<0.05). Besides, CD8+, CD3+ and CD4+ were lower than in those treated with β-lactams or non-β-lactams alone(all P<0.05). Conclusion Treatment with β-lactams combined with non-β-lactams antibiotics greatly influences intestinal microecology and peripheral blood T lymphocyte subsets in infants.