乏氧响应型纳米药物的设计、合成及其抗肿瘤作用研究

Design,Synthesis and Anti-tumor Activity of Hypoxia-Responsive Nanomedicines

乏氧是实体肿瘤的主要特征之一,不仅在血管生成、肿瘤转移等方面起到了举足轻重的作用,还能促进肿瘤细胞产生耐药性,从而削弱化疗、放疗和光动力疗法等治疗作用。同时,肿瘤乏氧区域表现出来的低氧特征以及高度生物还原性微环境也为设计响应型抗癌纳米药物提供了可能。综述基于肿瘤乏氧而发展起来的化疗前药和治疗策略,重点阐述近年来涌现的一类可响应乏氧进行药物释放/治疗的纳米药物体系,以期为临床抗肿瘤研究提供新的思路。

As a typical hallmark of solid tumor,hypoxia is not only strongly associated with angiogenesis and tumor metastasis,but also likely to produce tolerance of cancer cells,thus reducing the therapeutic effects of cancer therapies such as chemotherapy,radiotherapy and photodynamic therapy.Nevertheless,low oxygen level and highly bioreductive microenvironment offer us the potential opportunities to design hypoxia-responsive antitumor nanomedicines.This review briefly summarizes the development of hypoxia-activated prodrugs and their therapeutic strategies,with special attention to the novel hypoxia-responsive nano-drug delivery systems that have emerged in recent years,so as to pave a new way for antitumor clinical research.