福州地区无偿献血人群HIV-1新近感染情况的回顾性分析

The Recent HIV-1 Infections in Blood Donors of Fuzhou Zone

目的:了解福州地区无偿献血人群HIV-1新近感染的情况。方法:收集2012至2016年福州地区HIV抗体确证阳性标本,对所有标本采用限制性抗原亲和力酶联免疫法检测,以确定新近感染或既往感染的情况。结果:2012至2016年共对405 371份无偿献血者血液标本进行HIV项目检测,共收集HIV抗体确证阳性标本94份,经检测判定为新近感染标本共35份,每年HIV-1新近感染率分别为1.326‱、0.845‱、0.694‱、1.148‱和0.364‱,均值为0.863‱。94份确证阳性的标本中,初次献血者与重复献血者分别为58和36例,其中判定为新近感染标本分别为17份和18份,新近感染例数分别占29.3%和50.0%,差异有统计学意义(χ^(2)=4.07,P <0.05)。结论:福州地区无偿献血人群HIV-1新近感染率总体较为稳定,HIV抗体确证阳性重复献血者新近感染的占比明显高于初次献血者。

Objective:To investigate the recent HIV-1 infections of the blood donors in Fuzhou zone.Methods:The positive HIV antibody confirmatory samples in Fuzhou zone from 2012 to 2016 were collected and tested by LAg-Avidity EIA,and HIV long-term infections or recent infections were determined.Results:405 371 cases of blood donors were tested in the period from 2012 to 2016,and 94 HIV confirmatory positive samples were collected.35 cases were recent infections determined by LAg-Avidity EIA,the annual HIV-1 incidences were 1.326‱,0.845‱,0.694‱,1.148‱and 0.364‱,the average incidences were 0.863‰.Among 94 cases of HIV confirmatory positive donors 58 cases were first donors and 36 cases were repeated donors,17(29.3%) and 18(50.0%) cases were recent infections respectively,which showed statistical significance(χ^(2)=4.07,P <0.05).Conclusion:The HIV-1 incidences were stable among blood donors in Fuzhou zone.The percentage of HIV-1 recent infections in repeated donors were more higher than that in first donors.