基于数据挖掘的中药专利复方治疗慢性胆囊炎的用药规律分析

Analysis of Medication Rules of Traditional Chinese Medicine Patent Compound Based on Data Mining for Chronic Cholecystitis

目的探讨中药专利复方治疗慢性胆囊炎的用药规律。方法使用中国专利数据库检索治疗慢性胆囊炎的中药处方,建立Excel数据表对处方进行筛选处理,应用古今医案云平台软件对数据进行分析。结果筛选治疗慢性胆囊炎的复方170个,用药以寒性、苦味为主,归经以肝经为主。使用频次前10位的中药分别为柴胡、甘草、郁金、金钱草、茵陈、白芍、大黄、川楝子、黄芩、延胡索;关联规则显示药物以白芍-柴胡、白芍-甘草、黄芩-柴胡、大黄-金钱草、川楝子-柴胡、川楝子-郁金、川楝子-金钱草配伍较多;聚类分析得到7类药物组合;复杂网络分析得到30味核心中药和3组核心药物网络配伍。结论治疗慢性胆囊炎的中药专利复方药物性味以苦寒为主,多归肝经,用药以疏肝利胆、清热利湿、理气活血、泻下通腑类药物为主,配伍以疏肝柔肝、缓急止痛、和解表里、清热利湿、疏肝利胆为主,治疗上常用四逆散、金铃子散、大柴胡汤、茵陈蒿汤等方进行加减。

OBJECTIVE To discuss the medication rule of traditional Chinese medicine patent compound for treating chronic cholecystitis. METHODS Search for Chinese medicine prescriptions for treating chronic cholecystitis through China patent database, establish an Excel data sheet to screen and process prescriptions, and use ancient and modern medical record cloud platform software to analyze the data. RESULTS The 170 compound prescriptions for the treatment of chronic cholecystitis were screened, the drugs were mainly cold and bitter, and the main meridian was liver meridian. The top 10 Chinese medicines used frequently were Radix Bupleuri, Glycyrrhizae Radix et Rhizoma, Curcumae Radix, Lysimachiae Herba, Artemisiae Scopariae Herba, Paeoniae Radix Alba, Radix Rhei et Rhizome, Toosendan Fructus, Scutellariae Radix, Corydalis Rhizoma. Association rules showed that the medicines were more compatible with Paeoniae Radix Alba-Radix Bupleuri, Paeoniae Radix Alba-Glycyrrhizae Radix et Rhizoma, Scutellariae Radix-Radix Bupleuri, Radix Rhei Et Rhizome-Lysimachiae Herba, Toosendan Fructus-Radix Bupleuri, Toosendan Fructus-Curcumae Radix, Toosendan Fructus-Lysimachiae Herba. Cluster analysis obtained 7 types of drug combinations. Complex network analysis obtained 30 core Chinese medicines and 3 groups of core drug compatibility. CONCLUSION The Chinese medicine patent compound for treating chronic cholecystitis is mainly bitter and cold, and mainly enters the liver meridian. The efficacy of the medicine is mainly to disperse stagnated liver Qi for promoting bile flow, clear away heat and dampness, regulate Qi and promote blood circulation, and purify the lower organs. The main drug compatibility is to relieve liver and soften liver, relieving spasm and pain, reconcile superficies and interior, clear heat and dampness, and disperse stagnated liver Qi for promoting bile flow. In terms of treatment, Sini Powder, Jinlingzi Powder, Dachaihu Decoction, and Yinchenhao Decoction are often used.