奥拉替尼合成及应用研究进展

Progress in Synthesis and Application of Oclacitinib

奥拉替尼(Oclacitinib)是一种新型、高效的非受体络氨酸激酶(JAK)抑制剂,用于控制犬类的过敏性皮肤病引起的瘙痒。综述了近年来奥拉替尼的研究进展,介绍和评述了合成路线及方法、药物应用研究。展望了奥拉替尼药物未来的发展趋势。

As a novel and highly effective janus kinase(JAK)inhibitor,for the control of pruritus caused by atopic and allergic skin disease in dogs.The research progress of oclacitinib in recent years was reviewed,with emphasis on the introduction and review of synthetic routes and methods,and the application of drugs.Finally,the future development trend of oclacitinib drugs was prospected.