摘要
组学技术的运用主要基于高通量分析检测技术,包括转录组学、蛋白质组学和代谢组学等。生物信息学的飞速发展,为探索中药治疗疾病的机制提供新的思路和方法。在过去的数十年间,组学技术广泛应用于中药作用机制的研究当中。中药具有多成分、多靶点的特点,单一通路研究难以诠释中药"整体观念"的治疗思想,而多组学联用研究与这一观点不谋而合。查阅近年文献,对转录组学、蛋白质组学、代谢组学及16S rRNA测序等联用在中药治疗疾病中发挥的作用进行综述。
The application of omics techniques is mainly based on high-throughput analysis and detection techniques,including transcriptomics,proteomics and metabolomics.The rapid development of bioinformatics provides new ideas and methods for exploring the mechanism of traditional Chinese medicine(TCM).In the past few decades,omics technologies are widely used in the mechanism study of TCM.Multi-components and multi-targets are important features of TCM.Therefore,it is difficult to explain the"holism"concept of TCM using single pathway research,and multi-omics studies are consistent with this view.In this paper,by searching for recent literatures,the usage of transcriptomics,proteomics,metabolomics,and 16 S rRNA sequencing in the mechanism studies of TCM were reviewed.
作者
张改君
苗静
郭丽颖
贾建伟
崔换天
ZHANG Gai-jun;MIAO Jing;GUO Li-ying;JIA Jian-wei;CUI Huan-tian(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Second People’s Hospital,Tianjin 300192,China;Shandong Key Laboratory of Animal Cell and Developmental Biology,School of Life Sciences,Shandong University,Jinan 266237,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第10期3112-3120,共9页
Chinese Traditional and Herbal Drugs
基金
国家中医药防治传染病重点研究室建设项目[国中医药函(2010)34号]
天津市中医药管理局中医中西医结合科研课题(2019132)。
关键词
组学技术
中药
多组学
机制研究
转录组学
蛋白质组学
代谢组学
16S
rRNA测序
omics technologies
traditional Chinese medicine
multi-omics
mechanism study
transcriptomics
proteomics
metabolomics
16S rRNA sequencing
